Hilton D A, Love S, Fletcher A, Pringle J H
Department of Neuropathology, Frenchay Hospital, Bristol, UK.
J Neurol Neurosurg Psychiatry. 1994 Aug;57(8):975-6. doi: 10.1136/jnnp.57.8.975.
Epidemiological and serological evidence has suggested a role for Epstein-Barr virus infection in the aetiology of multiple sclerosis. Epstein-Barr virus-specific RNA was looked for in the brains of 10 patients with multiple sclerosis by in situ hybridisation. A total of 21 plaques was examined. In all of these preservation of RNA was shown by hybridisation of control probes to mitochondrial rRNA but no signal was detected with the Epstein-Barr virus probes. It is unlikely that persistent or latent Epstein-Barr virus infection of the CNS occurs in multiple sclerosis, although present findings do not exclude a role for Epstein-Barr virus in the initiation of this disorder.
流行病学和血清学证据表明，爱泼斯坦-巴尔病毒感染在多发性硬化症的病因学中起一定作用。通过原位杂交在10例多发性硬化症患者的大脑中寻找爱泼斯坦-巴尔病毒特异性RNA。共检查了21个斑块。在所有这些斑块中，对照探针与线粒体rRNA杂交显示RNA保存良好，但用爱泼斯坦-巴尔病毒探针未检测到信号。在多发性硬化症中，中枢神经系统不太可能发生爱泼斯坦-巴尔病毒的持续或潜伏感染，尽管目前的研究结果不排除爱泼斯坦-巴尔病毒在这种疾病的起始阶段起作用。
