Drew H J, Vogel R I, Molofsky W, Baker H, Frank O
J Clin Periodontol. 1987 Jul;14(6):350-6. doi: 10.1111/j.1600-051x.1987.tb00983.x.
There have been some reports that folic acid inhibits phenytoin-induced gingival hyperplasia. The purpose of this double-blind study was to quantify clinically the effects of both systemic and topical administration of folic acid on phenytoin-induced gingival overgrowth in man. For a period of 6 months, one group of phenytoin patients received 2 daily topical applications of a folate solution. An additional group received 2 daily doses of systemic folate while a control group received placebo medication. Results indicate that throughout the 180-day period of the study, the topical folate significantly inhibited gingival hyperplasia to a greater extent than either systemic folate or placebo groups.
有一些报道称叶酸可抑制苯妥英钠引起的牙龈增生。这项双盲研究的目的是从临床角度量化叶酸全身给药和局部给药对人体苯妥英钠引起的牙龈过度生长的影响。在6个月的时间里，一组服用苯妥英钠的患者每天接受两次局部叶酸溶液涂抹。另一组患者每天接受两次叶酸全身给药，而对照组则接受安慰剂治疗。结果表明，在整个180天的研究期间，局部使用叶酸比全身使用叶酸或安慰剂组更能显著抑制牙龈增生。
