Bio-Medical Research Center, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.
Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, China.
FASEB J. 2020 Dec;34(12):15647-15658. doi: 10.1096/fj.202000911R. Epub 2020 Oct 15.
Poly (rC)-binding protein 1 (PCBP1), an RNA- or DNA-binding protein with a relative molecular weight of 38 kDa, which is characterized by downregulation in many cancer types. Numerous cases have indicated that PCBP1 could be considered as a tumor suppressor to inhibit tumorigenesis, development, and metastasis. In the current review, we described the multilevel regulatory roles of PCBP1, including gene transcription, alternative splicing, and translation of many cancer-related genes. Additionally, we also provided a brief overview about the inhibitory effect of PCBP1 on most common tumors. More importantly, we summarized the current research status about PCBP1 in hypoxic microenvironment, autophagy, apoptosis, and chemotherapy of cancer cells, aiming to clarify the molecular mechanisms of PCBP1 in cancer. Taken together, in-depth study of PCBP1 in cancer may provide new ideas for cancer therapy.
聚（rC）结合蛋白 1（PCBP1）是一种相对分子质量为 38 kDa 的 RNA 或 DNA 结合蛋白，在许多癌症类型中表达下调。大量研究表明，PCBP1 可作为肿瘤抑制因子抑制肿瘤发生、发展和转移。在本综述中，我们描述了 PCBP1 的多层次调节作用，包括许多癌症相关基因的转录、选择性剪接和翻译。此外，我们还简要概述了 PCBP1 对大多数常见肿瘤的抑制作用。更重要的是，我们总结了 PCBP1 在肿瘤细胞缺氧微环境、自噬、凋亡和化疗中的研究现状，旨在阐明 PCBP1 在癌症中的分子机制。综上所述，深入研究癌症中的 PCBP1 可能为癌症治疗提供新的思路。
