Department of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng, China.
Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, Thailand.
Environ Toxicol. 2021 Mar;36(3):374-385. doi: 10.1002/tox.23043. Epub 2020 Oct 15.
Diabetic mellitus is a chronic metabolic disorder that is associated with several complications including testicular dysfunction. This research investigated the protective action of the ethyl acetate extract from Shorea roxburghii (SRE) on diabetes induced testicular damage in rats. Diabetic rats were orally administered with SRE at doses of 100 and 400 mg/kg for 4 weeks. SRE improved the body weight gain, testes weight, testes index and increased serum concentration of testosterone. Furthermore, SRE increased the testicular antioxidant enzymes including superoxide dismutase, catalase and glutathione peroxidase. In addition, SRE ameliorated testicular inflammatory mediators such as myeloperoxidase, tumor necrosis factor alpha, interleukin 6, p38 MAPK and nuclear factor kappa B activation and decreased testicular cell apoptosis in the treated diabetic rats. SRE also raised sperm parameters after treatment of diabetic rats. Conclusively, our results suggested that SRE ameliorated diabetes induced testicular damage by inhibiting oxidative stress and inflammation.
糖尿病是一种慢性代谢紊乱，与多种并发症有关，包括睾丸功能障碍。本研究探讨了来自娑罗双树（Shorea roxburghii）乙酸乙酯提取物（SRE）对糖尿病大鼠睾丸损伤的保护作用。糖尿病大鼠连续 4 周每天口服给予 SRE 100 和 400mg/kg。SRE 可改善体重增加、睾丸重量、睾丸指数，并提高血清睾酮浓度。此外，SRE 增加了睾丸抗氧化酶，包括超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶。此外，SRE 改善了糖尿病大鼠的睾丸炎症介质，如髓过氧化物酶、肿瘤坏死因子-α、白细胞介素 6、p38 MAPK 和核因子 κB 的激活，并减少了睾丸细胞凋亡。SRE 还改善了糖尿病大鼠的精子参数。总之，我们的结果表明，SRE 通过抑制氧化应激和炎症来改善糖尿病引起的睾丸损伤。
