Institute for Clinical Research and Health Policy Studies, Center for Clinical Evidence Synthesis, Tufts Medical Center, Boston, MA, USA.
J Altern Complement Med. 2021 Jan;27(1):3-11. doi: 10.1089/acm.2020.0236. Epub 2020 Oct 15.
Strenuous muscular workouts can increase markers of inflammation that can potentially damage components of skeletal muscles. Blueberries contain a variety of nutrients and phytochemicals that have individually been related to reduction in oxidative stress and inflammation. The objective was to conduct a systematic overview using evidence mapping to identify research-dense and evidence gap areas that examine the impact of blueberry consumption on exercise performance and inflammatory markers in adults. The authors searched Medline, Cochrane Central, and Commonwealth Agricultural Bureau for literature published between 1946 and September 2019. Abstracts and full-text publications were screened in duplicate for studies that evaluated outcomes related to metabolism, lipoprotein, muscle damage, markers of oxidative stress, inflammatory markers, or gait after participants consumed blueberries and were subjected to some form of exercise. The authors found nine randomized controlled trials, one single-arm study, and one observational study that met the eligibility criteria. Inflammatory markers, F2-isoprostanes, and gait speed were the most frequently reported outcomes, with each one reported by at least three studies. Outcomes related to metabolism, lipoproteins, muscle damage, and most markers of oxidative stress and most gait-related outcomes were each reported by one study. Intervention trials were generally conducted with a small number of participants and the majority included mostly younger individuals. Using multivariate analysis, the sole observational study examined physical ability among participants who consumed higher doses of blueberries compared with participants who consumed a half cup of blueberries less than once a month. Evidence mapping found that further research in both randomized controlled trials and cohort studies examining the impact of blueberry consumption on exercise performance and inflammatory markers is needed to establish an association.
剧烈的肌肉锻炼会增加炎症标志物的水平，这些标志物可能会损害骨骼肌的成分。蓝莓含有多种营养物质和植物化学物质，这些物质单独作用于减少氧化应激和炎症。本研究的目的是通过证据图谱进行系统综述，以确定研究密集和证据空白的领域，这些领域检查蓝莓消费对成年人运动表现和炎症标志物的影响。作者在 1946 年至 2019 年 9 月期间在 Medline、Cochrane Central 和联邦农业局搜索文献。对评估与代谢、脂蛋白、肌肉损伤、氧化应激标志物、炎症标志物或参与者在食用蓝莓后进行某种形式的运动时步态相关的结果的研究进行了重复的摘要和全文筛选。作者发现了 9 项随机对照试验、1 项单臂研究和 1 项观察性研究符合入选标准。炎症标志物、F2-异前列腺素和步态速度是最常报告的结果，每个结果都至少有 3 项研究报告。与代谢、脂蛋白、肌肉损伤以及大多数氧化应激标志物和大多数与步态相关的结果相关的结果，每个结果都有 1 项研究报告。干预试验通常是在少量参与者中进行的，大多数研究对象都是年轻人。在使用多元分析时，唯一的观察性研究是检查与摄入蓝莓较少的参与者相比，摄入较高剂量蓝莓的参与者的身体能力。证据图谱发现，需要进一步进行随机对照试验和队列研究，以确定蓝莓消费对运动表现和炎症标志物的影响，从而建立相关性。
