Brown Jason R, Chinnaiyan Arul M
Rogel Cancer Center, Michigan Medicine, University of Michigan, Ann Arbor, Michigan.
Cancer Epidemiol Biomarkers Prev. 2020 Dec;29(12):2541-2555. doi: 10.1158/1055-9965.EPI-20-0796. Epub 2020 Oct 15.
Circular RNA (circRNA) is a covalently closed RNA structure that has several proposed functions related to cancer development. Recently, cancer-specific and tissue-specific circRNAs have been identified by high-throughput sequencing and are curated in publicly available databases. CircRNAs have features that are ideal properties of biomarkers, including conservation, abundance, and stability in plasma, saliva, and urine. Many circRNAs with predictive and prognostic significance in cancer have been described, and functional mechanisms for some circRNAs have been suggested. CircRNA also has great potential as a noninvasive biomarker for early cancer detection, although further investigation is necessary before clinical application is feasible.
环状RNA（circRNA）是一种共价闭合的RNA结构，具有多种与癌症发展相关的假定功能。最近，通过高通量测序鉴定出了癌症特异性和组织特异性的circRNA，并在公开可用的数据库中进行了整理。circRNA具有作为生物标志物的理想特性，包括在血浆、唾液和尿液中的保守性、丰度和稳定性。已经描述了许多在癌症中具有预测和预后意义的circRNA，并提出了一些circRNA的功能机制。circRNA作为早期癌症检测的非侵入性生物标志物也具有巨大潜力，尽管在临床应用可行之前还需要进一步研究。
