Quan Wenjun, Bello Kizito Eneye, Shueb Rafidah Hanim, Mustaffa Nazri
Department of Medicine, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan 16150, Malaysia.
Department of Microbiology, Faculty of Natural Science, Kogi State University (Prince Abubakar Audu University), Anyigba, Kogi State 1008, Nigeria.
Genes Dis. 2025 Mar 18;12(5):101605. doi: 10.1016/j.gendis.2025.101605. eCollection 2025 Sep.
Circular RNAs (circRNAs) are a class of stable and versatile non-coding RNAs that are pivotal in the occurrence and development of some diseases, particularly tumors. Hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC) is a liver disease with substantial global impact. Despite efforts towards adequate management, the survival of patients with HBV-induced HCC has been consistently low. circRNAs regulate various physiological activities of HBV-induced HCC. This review aims to elucidate the biogenesis of circRNAs and the pathophysiology of HBV-induced HCC and comprehensively analyze the applications of circRNAs in oncology and therapeutics. In addition, this review summarizes past research achievements on circRNAs in HBV-induced HCC. Finally, the limitations of existing methodologies and circRNA research in HBV-induced HCC have been discussed to provide a blueprint for future investigations.
环状RNA（circRNAs）是一类稳定且多功能的非编码RNA，在某些疾病尤其是肿瘤的发生和发展中起关键作用。乙型肝炎病毒（HBV）诱导的肝细胞癌（HCC）是一种对全球有重大影响的肝脏疾病。尽管在进行充分管理方面做出了努力，但HBV诱导的HCC患者的生存率一直很低。circRNAs调节HBV诱导的HCC的各种生理活动。本综述旨在阐明circRNAs的生物发生以及HBV诱导的HCC的病理生理学，并全面分析circRNAs在肿瘤学和治疗学中的应用。此外，本综述总结了过去关于circRNAs在HBV诱导的HCC中的研究成果。最后，讨论了现有方法的局限性以及HBV诱导的HCC中circRNA研究的局限性，为未来的研究提供蓝图。
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