Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Pathol Res Pract. 2021 Nov;227:153640. doi: 10.1016/j.prp.2021.153640. Epub 2021 Sep 28.
Gastric cancer (GC) is one of the most commonly diagnosed neoplasms in the world. A number of environmental and lifestyle factors, particularly chronic infection with Helicobacter pylori, have been found to partake in the pathogenesis of GC. The advent of high-throughput genome and transcriptome analysis has enhanced the knowledge about molecular mechanisms of the pathogenesis of GC. However, data regarding the expression of several circRNAs, such as circLMTK2, are not consistent. We explain the role of circRNAs in the development of GC. We searched databases for the newest publications using the terms gastric cancer and circRNA. Each circRNA alteration, downstream targets, its impacts on cancer cells, and the prognostic and diagnostic roles of these circRNAs have been discussed. Taken together, circRNAs can be putative biomarkers in GC and potential targets for the treatment of this cancer. Yet, this field is still in its infancy and needs further experiments for reaching the clinical application. As these transcripts are stable in circulation, they can be used in non-invasive methods of cancer detection and patients' follow-up.
胃癌（GC）是世界上最常见的肿瘤之一。一些环境和生活方式因素，特别是慢性感染幽门螺杆菌，已被发现参与 GC 的发病机制。高通量基因组和转录组分析的出现提高了人们对 GC 发病机制分子机制的认识。然而，关于一些 circRNAs 的表达数据，如 circLMTK2，并不一致。我们解释了 circRNAs 在 GC 发展中的作用。我们使用了“胃癌”和“circRNA”这两个术语在数据库中搜索最新的出版物。讨论了每个 circRNA 的改变、下游靶点、对癌细胞的影响，以及这些 circRNAs 的预后和诊断作用。总之，circRNAs 可以作为 GC 的潜在生物标志物和治疗这种癌症的潜在靶点。然而，该领域仍处于起步阶段，需要进一步的实验才能应用于临床。由于这些转录本在循环中稳定存在，因此可以用于癌症检测和患者随访的非侵入性方法。
