Pediatric Department.
Tropical Medicine Department.
J Clin Gastroenterol. 2021 Oct 1;55(9):815-820. doi: 10.1097/MCG.0000000000001443.
Vitamin D has anti-inflammatory and immune regulatory functions.
The authors investigated the effect of vitamin D supplementation in children with inflammatory bowel disease (IBD) and hypovitaminosis D on disease activity, quality of life (QOL), inflammatory markers, and cytokines.
This randomized double-blinded controlled clinical trial included 120 children with IBD and hypovitaminosis D; 22 of them were excluded later. Patients were randomized to receive either oral vitamin D3 in a dose of 2000 IU/day or placebo for 6 months. The primary outcome was to evaluate the effect of vitamin D supplementation on the IBD activity score. The secondary outcomes were to assess the QOL, inflammatory markers, cytokines, the safety of vitamin D, and to correlate serum vitamin D level with various clinical and laboratory variables.
Vitamin D supplementation significantly decreased the IBD activity score in the vitamin D group compared with the placebo group. Moreover, QOL significantly improved after vitamin D supplementation. Inflammatory markers, for example, erythrocyte sedimentation rate, C-reactive protein, and fecal calprotectin and interleukin-2 IL-12, IL-17, IL-23, and tumor necrosis factor-alpha significantly decreased in the vitamin D group. However, IL-10 significantly increased after vitamin D supplementation. Vitamin D was significantly inversely correlated with the activity score, QOL score, levels of all inflammatory markers, the frequency of hospitalization, and emergency department visits.
Vitamin D supplementation may have a beneficial effect in children with IBD.
维生素 D 具有抗炎和免疫调节功能。
作者研究了补充维生素 D 对炎症性肠病（IBD）和维生素 D 缺乏儿童的疾病活动、生活质量（QOL）、炎症标志物和细胞因子的影响。
这是一项随机双盲对照临床试验，纳入了 120 例 IBD 和维生素 D 缺乏的儿童；其中 22 例后来被排除。患者被随机分为口服维生素 D3 组（剂量为 2000IU/天）或安慰剂组，疗程为 6 个月。主要结局是评估维生素 D 补充对 IBD 活动评分的影响。次要结局是评估 QOL、炎症标志物、细胞因子、维生素 D 的安全性，并将血清维生素 D 水平与各种临床和实验室变量相关联。
与安慰剂组相比，维生素 D 补充组的 IBD 活动评分显著降低。此外，维生素 D 补充后 QOL 显著改善。炎症标志物，如红细胞沉降率、C 反应蛋白和粪便钙卫蛋白以及白细胞介素-2（IL-2）、IL-12、IL-17、IL-23 和肿瘤坏死因子-α（TNF-α），在维生素 D 组显著降低。然而，IL-10 在维生素 D 补充后显著增加。维生素 D 与活动评分、QOL 评分、所有炎症标志物水平、住院频率和急诊科就诊次数呈显著负相关。
维生素 D 补充可能对 IBD 儿童有益。
