Wu Qi, Luo Yi, Lu Han, Xie Tiantian, Hu Zuomin, Chu Zhongxing, Luo Feijun
Hunan Key Laboratory of Grain-Oil Deep Process and Quality Control, Hunan Key Laboratory of Forestry Edible Resources Safety and Processing, Central South University of Forestry and Technology, Changsha 410004, China.
Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China.
Foods. 2024 Mar 15;13(6):898. doi: 10.3390/foods13060898.
Inflammatory bowel disease (IBD) includes ulcerative colitis and Crohn's disease, and it is a multifactorial disease of the intestinal mucosa. Oxidative stress damage and inflammation are major risk factors for IBD. Vitamin E has powerful antioxidant and anti-inflammatory effects. Our previous work and other investigations have shown that vitamin E has a positive effect on the prevention and treatment of IBD. In this paper, the source and structure of vitamin E and the potential mechanism of vitamin E's role in IBD were summarized, and we also analyzed the status of vitamin E deficiency in patients with IBD and the effect of vitamin E supplementation on IBD. The potential mechanisms by which vitamin E plays a role in the prevention and treatment of IBD include improvement of oxidative damage, enhancement of immunity, maintenance of intestinal barrier integrity, and suppression of inflammatory cytokines, modulating the gut microbiota and other relevant factors. The review will improve our understanding of the complex mechanism by which vitamin E inhibits IBD, and it also provides references for doctors in clinical practice and researchers in this field.
炎症性肠病（IBD）包括溃疡性结肠炎和克罗恩病，是一种肠道黏膜的多因素疾病。氧化应激损伤和炎症是IBD的主要危险因素。维生素E具有强大的抗氧化和抗炎作用。我们之前的工作及其他研究表明，维生素E对IBD的防治具有积极作用。本文总结了维生素E的来源和结构，以及维生素E在IBD中发挥作用的潜在机制，还分析了IBD患者维生素E缺乏的状况以及补充维生素E对IBD的影响。维生素E在IBD防治中发挥作用的潜在机制包括改善氧化损伤、增强免疫力、维持肠道屏障完整性、抑制炎性细胞因子、调节肠道微生物群及其他相关因素。这篇综述将增进我们对维生素E抑制IBD复杂机制的理解，也为临床医生及该领域的研究人员提供参考。
