GSK, Siena, Italy.
GSK, Philadelphia, Pennsylvania.
Pediatr Infect Dis J. 2021 Feb 1;40(2):e66-e71. doi: 10.1097/INF.0000000000002957.
Neisseria meningitidis serogroup B (MenB) causes most meningitis outbreaks worldwide. We evaluated the ability of the 4-component MenB vaccine (4CMenB) to induce bactericidal activity against outbreak strains in adolescents.
Individual sera from 20 United States and 23 Chilean adolescents who received 2 doses of 4CMenB 2 months apart were assayed at prevaccination and 1 month after second dose using a human complement serum bactericidal antibody assay (hSBA) against a full or subset strain panel consisting of 14 MenB outbreak strains and 1 MenW hyperendemic strain collected between 2001 and 2017 in the United States, United Kingdom, and France. Bactericidal activity was determined as the percentage of adolescents with hSBA titer ≥1:4 or ≥1:8.
One month after the second 4CMenB dose, antibodies from 65% to 100% of the US adolescents were able to kill 12 of 15 strains at 1:4 dilution. The remaining 3 strains were killed by 45%, 25%, and 15% of US adolescent sera. Similar percentages exhibited hSBA titers of ≥1:8. Across a subset of 4 strains, point estimates for the percentages of Chilean and US adolescents with hSBA titers of ≥1:4 after the second 4CMenB dose were similar (100% for strain M27703, 74% vs. 80% for M26312, 52% vs. 45% for M08 0240745), except for strain M39090 (91% vs. 65%).
This study was the first to evaluate bactericidal activity elicited by a MenB vaccine against 15 outbreak strains. Two doses of 4CMenB elicited bactericidal activity against MenB outbreak strains and a hyperendemic MenW strain.
脑膜炎奈瑟菌 B 群（MenB）导致全球大多数脑膜炎爆发。我们评估了 4 组份 MenB 疫苗（4CMenB）在青少年中诱导针对暴发菌株杀菌活性的能力。
在接受 2 剂 4CMenB 相隔 2 个月后，来自 20 名美国和 23 名智利青少年的个体血清在接种前和第二次接种后 1 个月，使用针对包含 14 种 MenB 暴发菌株和 1 种 MenW 高流行菌株的完整或亚群菌株组的人补体血清杀菌抗体测定（hSBA）进行检测，这些菌株组在美国、英国和法国于 2001 年至 2017 年期间收集。杀菌活性被确定为 hSBA 滴度≥1：4 或≥1：8 的青少年百分比。
在第二次 4CMenB 接种后 1 个月，65%至 100%的美国青少年的抗体能够在 1：4 稀释度下杀死 15 株中的 12 株。其余 3 株分别被 45%、25%和 15%的美国青少年血清杀死。相似的百分比表现出 hSBA 滴度≥1：8。在 4 株亚群菌株中，第二次 4CMenB 接种后智利和美国青少年 hSBA 滴度≥1：4 的百分比的点估计值相似（M27703 菌株为 100%，M26312 菌株为 74%比 80%，M08 0240745 菌株为 52%比 45%），但 M39090 菌株除外（91%比 65%）。
这项研究首次评估了 MenB 疫苗针对 15 种暴发菌株引起的杀菌活性。两剂 4CMenB 引发了针对 MenB 暴发菌株和高流行 MenW 菌株的杀菌活性。
