Ruiz García Yara, Sohn Woo-Yun, Seib Kate L, Taha Muhamed-Kheir, Vázquez Julio A, de Lemos Ana Paula S, Vadivelu Kumaran, Pizza Mariagrazia, Rappuoli Rino, Bekkat-Berkani Rafik
GSK, Rockville, MD, USA.
Institute for Glycomics, Griffith University, Gold Coast, QLD, Australia.
NPJ Vaccines. 2021 Oct 29;6(1):130. doi: 10.1038/s41541-021-00388-3.
Infections with Neisseria meningitidis and Neisseria gonorrhoeae have different clinical manifestations, but the bacteria share up to 80-90% genome sequence identity. The recombinant meningococcal serogroup B (MenB) vaccine 4CMenB consists of four antigenic components that can be present in non-B meningococcal and gonococcal strains. This comprehensive review summarizes scientific evidence on the genotypic and phenotypic similarities between vaccine antigens and their homologs expressed by non-B meningococcal and gonococcal strains. It also includes immune responses of 4CMenB-vaccinated individuals and effectiveness and impact of 4CMenB against these strains. Varying degrees of strain coverage were estimated depending on the non-B meningococcal serogroup and antigenic repertoire. 4CMenB elicits immune responses against non-B meningococcal serogroups and N. gonorrhoeae. Real-world evidence showed risk reductions of 69% for meningococcal serogroup W clonal complex 11 disease and 40% for gonorrhea after 4CMenB immunization. In conclusion, functional antibody activity and real-world evidence indicate that 4CMenB has the potential to provide some protection beyond MenB disease.
脑膜炎奈瑟菌和淋病奈瑟菌感染有不同的临床表现，但这两种细菌的基因组序列同一性高达80-90%。重组B群脑膜炎球菌疫苗（MenB）4CMenB由四种抗原成分组成，这些成分也可能存在于非B群脑膜炎球菌和淋病菌株中。这篇综述总结了关于疫苗抗原与其在非B群脑膜炎球菌和淋病菌株中表达的同源物之间基因型和表型相似性的科学证据。它还包括接种4CMenB疫苗个体的免疫反应以及4CMenB对这些菌株的有效性和影响。根据非B群脑膜炎球菌血清群和抗原库的不同，估计有不同程度的菌株覆盖率。4CMenB可引发针对非B群脑膜炎球菌血清群和淋病奈瑟菌的免疫反应。实际证据表明，接种4CMenB后，W群脑膜炎球菌克隆复合体11疾病的风险降低了69%，淋病风险降低了40%。总之，功能性抗体活性和实际证据表明，4CMenB有可能在预防B群脑膜炎球菌疾病之外提供一些保护。
