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非体外循环全腔静脉肺动脉连接术的术后即刻及早期后遗症

Immediate and early post-operative sequelae of off-pump total cavopulmonary connection.

作者信息

Talwar Sachin, Divya Aabha, Makhija Neeti, Choudhary Shiv Kumar, Airan Balram

机构信息

Departments of Cardiothoracic and Vascular Surgery, All India Institute of Medical Sciences, New Delhi, 110029 India.

Cardiac Anaesthesiology, Cardiothoracic Centre, All India Institute of Medical Sciences, New Delhi, India.

出版信息

Indian J Thorac Cardiovasc Surg. 2018 Oct;34(4):468-475. doi: 10.1007/s12055-017-0638-3. Epub 2018 Jan 17.

Abstract

BACKGROUND

Extracardiac Fontan (ECF) is currently the final operation of choice for patients with a univentricular heart. Performing this procedure without cardiopulmonary bypass (CPB) carries potential benefits. In this study, we report the early results of ECF without CPB.

PATIENTS AND METHODS

Between 2012 and 2015, 72 consecutive patients underwent Fontan without CPB. Their medical records were examined in detail.

RESULTS

Mean age was 11.8 ± 5.2 (range 5 to 23, median 10) years. Intraoperative mean superior vena cava clamp time was 15.19 ± 3.8 min, and the inferior vena cava clamp time was 16.93 ± 3.31 min. There were three early deaths. No patient required conversion from off-CPB to CPB. Mean inotropic score was 4.73 ± 5.9 (range 0 to 25, median 2.5). Mean time to extubation was 9.5 ± 5.82 (range 3 to 29, median 8) hours. Pleural drainage in intensive care unit (ICU) was 551.57 ± 452.77 (median 470) ml, and mean ICU stay was 2.27 ± 3.09 (median 1.5) days. Mean daily pleural drainage after discharge from the ICU was 163.7 ± 88.01 (median 140) ml, and mean time to removal of pleural tubes was 15.76 ± 8.4 (median 14) days. Total hospital stay was 17.03 ± 8.62 (median 15) days. At an early follow-up of 2-40 (median 25) months, all survivors ( = 69) had a patent Fontan circuit with normal ventricular function on echocardiography. There were no late deaths or thromboembolic complications.

CONCLUSIONS

Off-pump ECF is a low-risk procedure that avoids the harmful effects of CPB. Post-operative course of these patients is predictable with substantial savings in costs.

摘要

背景

心外法洛四联症(ECF)目前是单心室心脏患者的最终手术选择。在无体外循环(CPB)的情况下进行该手术有潜在益处。在本研究中,我们报告了无CPB的ECF的早期结果。

患者和方法

2012年至2015年期间,72例连续患者接受了无CPB的法洛四联症手术。详细检查了他们的病历。

结果

平均年龄为11.8±5.2(范围5至23岁,中位数10岁)。术中平均上腔静脉钳夹时间为15.19±3.8分钟,下腔静脉钳夹时间为16.93±3.31分钟。有3例早期死亡。没有患者需要从非CPB转换为CPB。平均肌力评分是4.73±5.9(范围0至25,中位数2.5)。平均拔管时间为9.5±5.82(范围3至29,中位数8)小时。重症监护病房(ICU)的胸腔引流量为551.57±452.77(中位数470)毫升,平均ICU住院时间为2.27±3.09(中位数1.5)天。从ICU出院后平均每日胸腔引流量为163.7±88.01(中位数140)毫升,平均胸腔引流管拔除时间为15.76±8.4(中位数14)天。总住院时间为17.03±8.62(中位数15)天。在2至40(中位数25)个月的早期随访中,所有幸存者(n = 69)的法洛四联症循环通畅,超声心动图显示心室功能正常。没有晚期死亡或血栓栓塞并发症。

结论

非体外循环ECF是一种低风险手术,可避免CPB的有害影响。这些患者的术后病程可预测,且成本大幅节省。

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