Univ Paris Sud, UMR CNRS 8612, Faculté de Pharmacie, 5 rue Jean-Baptiste Clément, 92296, Châtenay-Malabry, France.
Pharm Res. 2010 Jan;27(1):1-16. doi: 10.1007/s11095-009-0001-5. Epub 2009 Nov 10.
Perfluorocarbons (PFCs) are fluorinated compounds that have been used for many years in clinics mainly as gas/oxygen carriers and for liquid ventilation. Besides this main application, PFCs have also been tested as contrast agents for ultrasonography and magnetic resonance imaging since the end of the 1970s. However, most of the PFCs applied as contrast agents for imaging were gaseous. This class of PFCs has been recently substituted by liquid PFCs as ultrasound contrast agents. Additionally, liquid PFCs are being tested as contrast agents for (19)F magnetic resonance imaging (MRI), to yield dual contrast agents for both ultrasonography and (19)F MRI. This review focuses on the development and applications of the different contrast agents containing liquid perfluorocarbons for ultrasonography and/or MRI: large and small size emulsions (i.e. nanoemulsions) and nanocapsules.
全氟碳化合物（PFCs）是一种氟化化合物，多年来主要作为气体/氧气载体和液体通气剂在临床上使用。除了这一主要用途外，自 20 世纪 70 年代末以来，PFCs 也被用作超声和磁共振成像的造影剂进行测试。然而，作为成像造影剂应用的大多数 PFCs 都是气态的。最近，这一类 PFCs 已被用作超声造影剂的液态 PFCs 所取代。此外，液态 PFCs 也被测试用作（19）F 磁共振成像（MRI）的造影剂，以产生用于超声和（19）F MRI 的双重造影剂。本综述重点介绍了不同含液态全氟碳化合物的造影剂在超声和/或 MRI 中的开发和应用：大、小粒径乳液（即纳米乳液）和纳米胶囊。
