埃塞俄比亚阿姆哈拉州东北部凯米西切法-罗比特健康中心急性腹泻病期间抗生素使用模式的评估

Evaluation of Antibiotic Utilization Pattern During Acute Diarrheal Disease at Chefa-Robit Health Center, Kemissie, North East Amhara, Ethiopia.

作者信息

Misganaw Desye, Abtew Kassaw

机构信息

Pharmacology and Toxicology Unit, Department of Pharmacy, College of Medicine and Health Science, Wollo University, Dessie, Ethiopia.

出版信息

Drug Healthc Patient Saf. 2020 Sep 28;12:169-175. doi: 10.2147/DHPS.S256330. eCollection 2020.

DOI:10.2147/DHPS.S256330

PMID:33061654

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7534044/

Abstract

BACKGROUND

Despite the fact that the majority of the acute diarrheal diseases are viral in origin and self-limited, routine and injudicious antibiotic treatment is a common practice globally and more prevalent in Africa. Indeed, the irrational use of antibiotics has a detrimental effect on the issue of antibiotics resistance and associated healthcare costs. Accordingly, a health center-based cross-sectional study is mandatory and was conducted due to the common malpractice of antibiotics use.

OBJECTIVE

The aim of this study was to evaluate the antibiotic use pattern in the treatment of acute diarrheal disease in Chefa-robit health center, Kemissie, Northeastern Ethiopia.

METHODS AND MATERIALS

A retrospective cross-sectional study was conducted to evaluate the antibiotic utilization pattern for the treatment of acute diarrheal disease. Data was collected from 230 patients' record cards treated for acute diarrheal disease from January 2018 to December 2018 using structured questionnaires. The finding is presented using frequency distribution and percentages in tables as well as figures.

RESULTS

Among the 230 patients, 49.60% were males and the rest were females. From the total, 172 of them were with watery type of diarrhea and 132 of them were prescribed antibiotics inappropriately out of which 77 were under 5 years. In addition, 27 patients were diagnosed with mucoid diarrhea and only eight of them were treated with antibiotics whereas 31 patients were with bloody type of diarrhea and 10 of them were not treated with antibiotics. Of the 230 cases, 161 (70%) patients received different types of antibiotics, and co-trimoxazole, amoxicillin and ciprofloxacin were the most prescribed antibiotics.

CONCLUSION

The study revealed that there is a high level of inappropriate antibiotics use which may fuel the increased antimicrobial resistance and associated costs nationally as well as globally.

摘要

背景

尽管大多数急性腹泻病起源于病毒且具有自限性，但常规且不合理的抗生素治疗在全球范围内都是常见做法，在非洲更为普遍。事实上，抗生素的不合理使用对抗生素耐药性问题和相关医疗成本产生了不利影响。因此，基于健康中心的横断面研究是必要的，并且由于抗生素使用的常见不当行为而开展了此项研究。

目的

本研究的目的是评估埃塞俄比亚东北部凯米西的切法-罗比特健康中心在治疗急性腹泻病时的抗生素使用模式。

方法和材料

开展了一项回顾性横断面研究，以评估治疗急性腹泻病时的抗生素使用模式。使用结构化问卷从2018年1月至2018年12月治疗急性腹泻病的230名患者的病历卡中收集数据。研究结果以表格和图表中的频率分布和百分比呈现。

结果

在230名患者中，49.60%为男性，其余为女性。其中，172人患有水样腹泻，其中132人被不恰当地开具了抗生素，其中77人年龄在5岁以下。此外，27名患者被诊断为黏液样腹泻，其中只有8人接受了抗生素治疗，而31名患者患有血性腹泻，其中10人未接受抗生素治疗。在230例病例中，161例（70%）患者接受了不同类型的抗生素治疗，复方新诺明、阿莫西林和环丙沙星是最常开具的抗生素。