Tulu Selamawit, Tadesse Tarekegne, Alemayehu Gube Addisu
Department of Pharmacy, College of Medicine and Health Sciences, Ambo University, P.O. Box 19, Ambo, Ethiopia.
Department of Public Health, College of Medicine and Health Sciences, Arba Minch University, P.O. Box 21, Arba Minch, Ethiopia.
Adv Med. 2018 May 2;2018:2376825. doi: 10.1155/2018/2376825. eCollection 2018.
Majority of acute diarrhoeal diseases are self-limiting and do not require routine treatment. Treatment with empirical antimicrobials is recommended only for dysenteric and invasive bacterial diarrhoea. Irrational use of antibiotics in treatment of acute diarrhoea is common in clinical practice worldwide. This study was carried out to assess the pattern of antibiotic use for acute diarrhoeal diseases in Bishoftu General Hospital, East Shewa Ethiopia.
Institution based cross-sectional study was conducted from April 1 to April 30, 2016. Data were collected retrospectively from patients treated for diarrhoeal diseases from January 2015 to December 2015 using structured questionnaires and entered into SPSS (IBM 20) and descriptive statistics was carried out.
Among the 303 patients, 51.2% were males and 48.8% were females. Of them, 62% were children under five years. Two hundred sixty three (86.8%) patients received eight different types of antibiotics and cotrimoxazole (178 patients, 58.7%) was the most prescribed antibiotics, followed by ciprofloxacin (33, 10.9%) and amoxicillin (14, 4.6%). Based on the presence of blood in stools, 14.5% of cases were of invasive bacterial type. According to the recommendations of WHO, the rate of overuse of antibiotics was 72.3%.
This study revealed that there was high overuse of antibiotics for both adults and children under five with acute diarrhoea in Bishoftu General Hospital. And Cotrimoxazole was the most prescribed antibiotic.
大多数急性腹泻病具有自限性,无需常规治疗。仅推荐对痢疾和侵袭性细菌性腹泻采用经验性抗菌药物治疗。在全球临床实践中,急性腹泻治疗中不合理使用抗生素的情况很常见。本研究旨在评估埃塞俄比亚东谢瓦比肖夫图综合医院急性腹泻病抗生素使用模式。
2016年4月1日至4月30日进行了基于机构的横断面研究。使用结构化问卷从2015年1月至2015年12月因腹泻病接受治疗的患者中回顾性收集数据,并录入SPSS(IBM 20)进行描述性统计分析。
303例患者中,男性占51.2%,女性占48.8%。其中,62%为五岁以下儿童。263例(86.8%)患者接受了八种不同类型的抗生素治疗,复方新诺明(178例,58.7%)是最常开具的抗生素,其次是环丙沙星(33例,10.9%)和阿莫西林(14例,4.6%)。根据粪便中是否带血,14.5%的病例为侵袭性细菌类型。根据世界卫生组织的建议,抗生素过度使用率为72.3%。
本研究表明,比肖夫图综合医院五岁以下儿童和成人急性腹泻的抗生素过度使用率都很高。复方新诺明是最常开具的抗生素。