埃塞俄比亚德布雷塔博尔综合专科医院急性腹泻病治疗中抗生素使用模式的评估：一项回顾性横断面研究。

Evaluation of antibiotic utilization pattern in the treatment of acute diarrheal diseases at Debre Tabor comprehensive specialized hospital, Debre Tabor, Ethiopia: A retrospective cross-sectional study.

作者信息

Addis Getu Tesfaw, Dagnew Samuel Berihun, Anagaw Alemnew, Ayele Teklie Mengie, Tadesse Tesfaye Yimer

机构信息

Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.

出版信息

Heliyon. 2023 Jul 7;9(7):e18049. doi: 10.1016/j.heliyon.2023.e18049. eCollection 2023 Jul.

DOI:10.1016/j.heliyon.2023.e18049

PMID:37449097

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10336787/

Abstract

BACKGROUND

In clinical settings all across the world, including Ethiopia, the irrational use of antibiotics to treat acute diarrhea is common. The main causes of resistance are antibiotic abuse, misuse, and underuse, and among infectious diseases, antibiotic overuse is pervasive in diarrheal infections around the world. As a result, the primary goal of this study was to evaluate antibiotic use patterns for the treatment of acute diarrheal diseases at Debre Tabor Comprehensive Specialized Hospital in North-West Ethiopia.

METHODOLOGY

A retrospective cross-sectional study was conducted to assess the antibiotic utilization pattern used to treat acute diarrheal illness, taken from the record cards of 243 patients who received treatment for acute diarrheal illness, employing structured questions from September 1 to September 30, 2022. The results are displayed using percentages and frequency distributions in tables along with figures.

RESULTS

A total of 243 patients were involved, 134 (55.1%) of whom were male and 134 (55.1%) were under the age of five. Out of the 103 cases of acute watery diarrhea, 83 received antibiotics that were given improperly. Additionally, 88 individuals had bloody diarrhea diagnoses, but 58 of them received the currently administered antibiotics. Amoxicillin and co-trimoxazole were the most frequently prescribed medications, with 193 (79.5%) of the 243 cases of patients receiving some form of antibiotic.

CONCLUSION

The results of the study revealed that there is inappropriate antibiotic use in acute diarrheal disease at Debre Tabor Comprehensive Specialized Hospital, which might be the cause for the overall increase in antimicrobial resistance as well as the associated costs of treatment. The finding is helpful as evidence for prescribers' inappropriate use of antibiotics for the treatment of acute diarrheal sickness.

摘要

背景

在包括埃塞俄比亚在内的世界各地的临床环境中，不合理使用抗生素治疗急性腹泻的情况很常见。耐药性的主要原因是抗生素的滥用、误用和使用不足，在传染病中，抗生素的过度使用在全球腹泻感染中普遍存在。因此，本研究的主要目的是评估埃塞俄比亚西北部德布雷塔博尔综合专科医院治疗急性腹泻疾病的抗生素使用模式。

方法

进行了一项回顾性横断面研究，以评估用于治疗急性腹泻疾病的抗生素使用模式，数据取自2022年9月1日至9月30日接受急性腹泻疾病治疗的243名患者的病历卡，并采用结构化问题。结果以表格形式用百分比和频率分布以及图表展示。

结果

总共涉及243名患者，其中134名（55.1%）为男性，134名（55.1%）年龄在五岁以下。在103例急性水样腹泻病例中，83例接受了不当使用的抗生素。此外，88人被诊断为血性腹泻，但其中58人接受了目前使用的抗生素。阿莫西林和复方新诺明是最常开具的药物，243例患者中有193例（79.5%）接受了某种形式抗生素治疗。