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埃塞俄比亚西谢瓦州安博综合医院接受高效抗逆转录病毒治疗(HAART)的艾滋病毒/艾滋病患者健康相关生活质量及相关因素评估

Assessment of Health-Related Quality of Life and Associated Factors Among HIV/AIDS Patients on Highly Active Antiretroviral Therapy (HAART) at Ambo General Hospital, West Shewa, Ethiopia.

作者信息

Dinsa Ayeno Hunduma, Megersa Atomsa Kume, Melesie Taye Getu

机构信息

Department of Pharmacy, College of Medicine and Health Sciences, Ambo University, Ambo, Ethiopia.

出版信息

HIV AIDS (Auckl). 2020 Sep 25;12:467-478. doi: 10.2147/HIV.S259510. eCollection 2020.

DOI:10.2147/HIV.S259510
PMID:33061658
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7524170/
Abstract

BACKGROUND

Determining the degree of health-related quality of life (HRQoL) and associated factors in human immunodeficiency virus (HIV)-positive people is of great importance.

OBJECTIVE

The aim of this study was to assess the HRQoL and associated factors among HIV-infected patients who were on highly active antiretroviral therapy (HAART) at Ambo General Hospital.

METHODS

A study with a cross-sectional design was conducted on 296 HIV-infected patients who were on HAART at Ambo General Hospital from February 20 to May 20, 2019. Patients were recruited by a random sampling technique and a -value <0.05 was set as statistically significant. Th main outcome measure was HRQoL.

RESULTS

The majority of study participants were female (56.8%). More than half (53%) of the participants had low overall HRQoL. Those who were married and who earned <1500 ETB were less likely to experience low overall HRQoL than single people (AOR: 4.41, =0.024) and those who earned more (AOR: 4.27, =0.000), respectively. Those with current illness and who had no HIV-positive family members were more likely to experience lower overall quality of life than those with no current illness (AOR: 32.29, =0.000) and with one HIV-positive family member (AOR: 4.03, =0.003), respectively. Those with recent WHO clinical stage I were less likely to experience a lower overall quality of life than those with stage II (AOR: 0.07, =0.000).

CONCLUSION

Current illness, recent WHO stage and having no HIV-positive family members were found to be strongly associated with lower quality of life in HIV-positive patients on antiretroviral therapy.

摘要

背景

确定人类免疫缺陷病毒(HIV)阳性人群的健康相关生活质量(HRQoL)程度及其相关因素至关重要。

目的

本研究旨在评估安博综合医院接受高效抗逆转录病毒治疗(HAART)的HIV感染患者的HRQoL及其相关因素。

方法

于2019年2月20日至5月20日对安博综合医院296例接受HAART的HIV感染患者进行了一项横断面研究。采用随机抽样技术招募患者,设定P值<0.05为具有统计学意义。主要结局指标为HRQoL。

结果

大多数研究参与者为女性(56.8%)。超过一半(53%)的参与者总体HRQoL较低。已婚且收入低于1500埃塞俄比亚比尔的参与者比单身者(调整后比值比[AOR]:4.41,P = 0.024)和收入较高者(AOR:4.27,P = 0.000)更不容易出现总体HRQoL较低的情况。患有当前疾病且没有HIV阳性家庭成员的患者比没有当前疾病的患者(AOR:32.29,P = 0.000)和有一名HIV阳性家庭成员的患者(AOR:4.03,P = 0.003)更有可能经历较低的总体生活质量。世界卫生组织(WHO)临床分期为I期的患者比II期患者更不容易出现较低的总体生活质量(AOR:0.07,P = 0.000)。

结论

发现当前疾病、近期WHO分期以及没有HIV阳性家庭成员与接受抗逆转录病毒治疗的HIV阳性患者较低的生活质量密切相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa4d/7524170/edbfcbee5f7f/HIV-12-467-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa4d/7524170/0cebdaf9e08d/HIV-12-467-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa4d/7524170/edbfcbee5f7f/HIV-12-467-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa4d/7524170/0cebdaf9e08d/HIV-12-467-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa4d/7524170/edbfcbee5f7f/HIV-12-467-g0002.jpg

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