Dinsa Ayeno Hunduma, Megersa Atomsa Kume, Melesie Taye Getu
Department of Pharmacy, College of Medicine and Health Sciences, Ambo University, Ambo, Ethiopia.
HIV AIDS (Auckl). 2020 Sep 25;12:467-478. doi: 10.2147/HIV.S259510. eCollection 2020.
Determining the degree of health-related quality of life (HRQoL) and associated factors in human immunodeficiency virus (HIV)-positive people is of great importance.
The aim of this study was to assess the HRQoL and associated factors among HIV-infected patients who were on highly active antiretroviral therapy (HAART) at Ambo General Hospital.
A study with a cross-sectional design was conducted on 296 HIV-infected patients who were on HAART at Ambo General Hospital from February 20 to May 20, 2019. Patients were recruited by a random sampling technique and a -value <0.05 was set as statistically significant. Th main outcome measure was HRQoL.
The majority of study participants were female (56.8%). More than half (53%) of the participants had low overall HRQoL. Those who were married and who earned <1500 ETB were less likely to experience low overall HRQoL than single people (AOR: 4.41, =0.024) and those who earned more (AOR: 4.27, =0.000), respectively. Those with current illness and who had no HIV-positive family members were more likely to experience lower overall quality of life than those with no current illness (AOR: 32.29, =0.000) and with one HIV-positive family member (AOR: 4.03, =0.003), respectively. Those with recent WHO clinical stage I were less likely to experience a lower overall quality of life than those with stage II (AOR: 0.07, =0.000).
Current illness, recent WHO stage and having no HIV-positive family members were found to be strongly associated with lower quality of life in HIV-positive patients on antiretroviral therapy.
确定人类免疫缺陷病毒(HIV)阳性人群的健康相关生活质量(HRQoL)程度及其相关因素至关重要。
本研究旨在评估安博综合医院接受高效抗逆转录病毒治疗(HAART)的HIV感染患者的HRQoL及其相关因素。
于2019年2月20日至5月20日对安博综合医院296例接受HAART的HIV感染患者进行了一项横断面研究。采用随机抽样技术招募患者,设定P值<0.05为具有统计学意义。主要结局指标为HRQoL。
大多数研究参与者为女性(56.8%)。超过一半(53%)的参与者总体HRQoL较低。已婚且收入低于1500埃塞俄比亚比尔的参与者比单身者(调整后比值比[AOR]:4.41,P = 0.024)和收入较高者(AOR:4.27,P = 0.000)更不容易出现总体HRQoL较低的情况。患有当前疾病且没有HIV阳性家庭成员的患者比没有当前疾病的患者(AOR:32.29,P = 0.000)和有一名HIV阳性家庭成员的患者(AOR:4.03,P = 0.003)更有可能经历较低的总体生活质量。世界卫生组织(WHO)临床分期为I期的患者比II期患者更不容易出现较低的总体生活质量(AOR:0.07,P = 0.000)。
发现当前疾病、近期WHO分期以及没有HIV阳性家庭成员与接受抗逆转录病毒治疗的HIV阳性患者较低的生活质量密切相关。