中国西南部云南省普通人群中sp.感染的分子流行病学及危险因素

Molecular Epidemiology and Risk Factors of sp. Infections Among General Populations in Yunnan Province, Southwestern China.

作者信息

Deng Yao, Zhang Shunxian, Ning Chaoqun, Zhou Yongkang, Teng Xuejiao, Wu Xiuping, Chu Yanhong, Yu Yingfang, Chen Jiaxu, Tian Liguang, Wang Wei

机构信息

Key Laboratory of National Health Commission on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi 214064, Jiangsu Province, People's Republic of China.

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Key Laboratory of National Health Commission on Parasites and Vector Biology, WHO Collaborating Center for Tropical Diseases, Chinese Center for Tropical Diseases Research, Shanghai 200025, People's Republic of China.

出版信息

Risk Manag Healthc Policy. 2020 Sep 29;13:1791-1801. doi: 10.2147/RMHP.S269664. eCollection 2020.

DOI:10.2147/RMHP.S269664

PMID:33061712

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7532910/

Abstract

BACKGROUND

is a common enteric parasite of controversial pathogenic roles in human diseases. Although the prevalence of infections has been investigated in a diverse range of populations, there is little knowledge on the molecular epidemiology and risk factors of infections among general populations in southeastern China.

MATERIALS AND METHODS

A total of 507 individuals were randomly selected in Yunnan province, China from July 2016 to March 2017. Stool specimens were sampled for detection of sp. using PCR assay, and the risk factors of infections were identified. isolates were subtyped, and the associations of infections and subtypes with clinical manifestations were examined.

RESULTS

The overall detection rate of sp. was 9.47% (95% : 7.13-12.44%). Toilet type ( = 3.248, 95% CI: 1.245-8.473), anemia ( = 2.601, 95% : 1.245-8.473) and type of daily drinking water ( = 3.11, 95% : 1.557-6.213) were identified as risk factors of infections; however, infections showed no associations with clinical symptoms. Four subtypes (ST1 to ST4) were characterized in isolates, in which ST3 was predominant (4.73%, 95% : 3.2-6.94%), followed by ST1 (3.16%, 95% : 1.95-5.07%), ST4 (1.38%, 95% : 0.07-2.82%) and ST2 (0.2%, 95% : 0-1.11%). In addition, ST1 subtype infection was found to correlate with anemia ( = 4.66, 95% : 1.631-14.314).

CONCLUSIONS

There is a high prevalence of infections among general populations in Yunnan province, southwestern China, and toilet type, anemia and type of daily drinking water are risk factors of infections. ST3 is the dominant subtype of sp. characterized, and ST1 correlates with anemia. Improving hygiene conditions, developing healthy lifestyles and intensifying health education programs are strongly recommended to reduce the prevalence and transmission potential of infections.

摘要

背景

是一种常见的肠道寄生虫，在人类疾病中的致病作用存在争议。尽管已在不同人群中调查了感染的流行情况，但对中国东南部普通人群中感染的分子流行病学和危险因素知之甚少。

材料与方法

2016年7月至2017年3月在中国云南省共随机选取507人。采集粪便标本，采用聚合酶链反应（PCR）检测法检测属物种，并确定感染的危险因素。对分离株进行亚型分型，并研究感染及亚型与临床表现的关联。

结果

属物种的总体检出率为9.47%（95%可信区间：7.13 - 12.44%）。厕所类型（ = 3.248，95%可信区间：1.245 - 8.473）、贫血（ = 2.601，95%可信区间：1.245 - 8.473）和日常饮用水类型（ = 3.11，95%可信区间：1.557 - 6.213）被确定为感染的危险因素；然而，感染与临床症状无关联。在分离株中鉴定出四种亚型（ST1至ST4），其中ST3占主导（4.73%，95%可信区间：3.2 - 6.94%），其次是ST1（3.16%，95%可信区间：1.95 - 5.07%）、ST4（1.38%，95%可信区间：0.07 - 2.82%）和ST2（0.2%，95%可信区间：0 - 1.11%）。此外，发现ST1亚型感染与贫血相关（ = 4.66，95%可信区间：1.631 - 14.314）。