Anyanwu Brilliance O, Orish Chinna N, Ezejiofor Anthonet N, Nwaogazie Ify L, Orisakwe Orish E
African Centre of Excellence for Oilfield Chemicals Research (ACE-CEFOR), University of Port Harcourt, PMB 5323, Port Harcourt, Choba, Nigeria.
Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, University of Port Harcourt, PMB 5323, Port Harcourt, Choba, Nigeria.
J Toxicol. 2020 Sep 29;2020:8850264. doi: 10.1155/2020/8850264. eCollection 2020.
The present work investigated the protective effects of Ker Gawl. aqueous leaf extract (CALE) on lipid profile and hematological changes induced by exposure to low-dose heavy metal mixture in male albino rats. The experimental animals were divided into six weight matched groups. The normal (group 1) and toxic (group 2) controls received deionized water and metal mixture (20 mg/kg PbCl, 1.61 mg/kg CdCl, and 0.40 mg/kg HgCl), respectively. Test rats in groups 3, 4, and 5 were treated with metal mixture and CALE (750, 1500, and 2250 mg/kg, respectively), and group 6 received metal mixture and ZnCl. All treatments were administered through oral gavage for 12 weeks. LDHMM caused a marked increase ( < 0.05) in cholesterol, triglyceride, low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL) levels and a decrease in high-density lipoprotein (HDL), percentage body weight gain, and feed and fluid intake. Also, a significant decrease in RBC, Hb, and PCV, a significant increase in WBC, and no significant increase in platelet PLT were observed in the metal mixture-treated group. But in CALE treated groups, their levels were found to attain almost normal values as found in normal control which is also similar to the zinc-treated group. may hold a promise in improving lipid profile and hemodynamic picture in cardiovascular diseases.
本研究调查了柯氏叶水提取物（CALE）对雄性白化大鼠暴露于低剂量重金属混合物所诱导的血脂谱和血液学变化的保护作用。将实验动物分为六个体重匹配组。正常对照组（第1组）和毒性对照组（第2组）分别给予去离子水和金属混合物（20mg/kg PbCl、1.61mg/kg CdCl和0.40mg/kg HgCl）。第3、4和5组的试验大鼠分别用金属混合物和CALE（分别为750、1500和2250mg/kg）进行处理，第6组接受金属混合物和ZnCl。所有处理均通过口服灌胃进行12周。低剂量重金属混合物导致胆固醇、甘油三酯、低密度脂蛋白（LDL）和极低密度脂蛋白（VLDL）水平显著升高（<0.05），高密度脂蛋白（HDL）、体重增加百分比、饲料和液体摄入量降低。此外，在金属混合物处理组中观察到红细胞、血红蛋白和红细胞压积显著降低，白细胞显著升高，血小板PLT无显著升高。但在CALE处理组中，发现其水平几乎达到正常对照组中的正常数值，这也与锌处理组相似。CALE在改善心血管疾病的血脂谱和血液动力学状况方面可能具有前景。
