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Circ_0072088通过吸附miR-377促进食管鳞状细胞癌的增殖、迁移和侵袭。

Circ_0072088 Promotes Proliferation, Migration, and Invasion of Esophageal Squamous Cell Cancer by Absorbing miR-377.

作者信息

Fang Na, Shi Yijun, Fan Yu, Long Tao, Shu Yongqian, Zhou Jianwei

机构信息

Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

Department of Molecular Cell Biology and Toxicology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.

出版信息

J Oncol. 2020 Sep 29;2020:8967126. doi: 10.1155/2020/8967126. eCollection 2020.

DOI:10.1155/2020/8967126
PMID:33061973
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7542490/
Abstract

Circular RNA (circRNA) is an endogenous noncoding RNA. Accumulative investigations have confirmed that circRNAs play a vital role in carcinogenesis and tumor progression. Herein, we examined the expression and mechanism of circ_0072088 in esophageal squamous cell carcinoma (ESCC). As a result, circ_0072088 was significantly overexpressed in ESCC tissues and cells, which was closely associated with tumor size, invasion depth, clinical stage, and lymph node metastasis of esophageal cancer. Nuclear and cytoplasmic separation as well as FISH assays showed that circ_0072088 was mainly localized in the cytoplasm of ESCC cells. RNase R treatment assay revealed that circ_0072088 was steadier than linear ZFR mRNA. circ_0072088 promoted ESCC cell proliferation, migration and invasion , and cell proliferation . Mechanistically, circ_0072088 upregulated VEGF gene expression by acting as the sponge of miRNA-377. In conclusion, circ_0072088 might be used as a diagnostic biomarker and therapeutic target for ESCC.

摘要

环状RNA（circRNA）是一种内源性非编码RNA。越来越多的研究证实，circRNA在肿瘤发生和肿瘤进展中起着至关重要的作用。在此，我们研究了circ_0072088在食管鳞状细胞癌（ESCC）中的表达及作用机制。结果显示，circ_0072088在ESCC组织和细胞中显著高表达，这与食管癌的肿瘤大小、浸润深度、临床分期及淋巴结转移密切相关。细胞核与细胞质分离以及荧光原位杂交实验表明，circ_0072088主要定位于ESCC细胞的细胞质中。核糖核酸酶R处理实验显示，circ_0072088比线性ZFR mRNA更稳定。circ_0072088促进ESCC细胞增殖、迁移和侵袭以及细胞增殖。机制上，circ_0072088通过充当miRNA - 377的海绵上调VEGF基因表达。总之，circ_0072088可能作为ESCC的诊断生物标志物和治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6afc/7542490/72cfdf1ec847/JO2020-8967126.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6afc/7542490/ec3b66602b62/JO2020-8967126.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6afc/7542490/e0006ac12670/JO2020-8967126.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6afc/7542490/e09d36aef484/JO2020-8967126.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6afc/7542490/b16b5e94900d/JO2020-8967126.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6afc/7542490/430ab4b98a31/JO2020-8967126.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6afc/7542490/72cfdf1ec847/JO2020-8967126.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6afc/7542490/ec3b66602b62/JO2020-8967126.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6afc/7542490/e0006ac12670/JO2020-8967126.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6afc/7542490/e09d36aef484/JO2020-8967126.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6afc/7542490/b16b5e94900d/JO2020-8967126.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6afc/7542490/430ab4b98a31/JO2020-8967126.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6afc/7542490/72cfdf1ec847/JO2020-8967126.006.jpg

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