Oncology Nursing Society.
Western Governor's University.
Oncol Nurs Forum. 2020 Nov 1;47(6):E225-E236. doi: 10.1188/20.ONF.E225-E236.
A systematic review and meta-analysis was conducted to inform the development of guidelines on the management of radiodermatitis among patients with cancer.
The authors updated a systematic review to include available literature published through September 30, 2019.
Two investigators assessed risk of bias using the Cochrane Collaboration risk-of-bias tool and certainty of the evidence using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach.
The use of deodorant/antiperspirant had no effect on development of radiodermatitis. Aloe vera and emu oil were equivalent or less effective than standard care. Oral curcumin had a minimal beneficial effect. Nonsteroidal topical interventions had a minimal beneficial effect on the development of moist desquamation and relief of itching while causing a small increase for grade 2 radiodermatitis. Topical calendula increased risk for the development of radiodermatitis. Topical steroids and dressings each showed benefits to minimize the development of radiodermatitis and moist desquamation while lowering rates of patient-reported symptoms, such as pain and pruritus.
Symptom management strategies for radiodermatitis among patients with cancer that are likely to be effective include topical nonsteroidals, topical steroids, and dressings.
SUPPLEMENTAL MATERIAL CAN BE FOUND AT HTTPS: //bit.ly/2FWj3Kp.
系统评价和荟萃分析旨在为癌症患者放射性皮炎管理指南的制定提供信息。
作者更新了一项系统评价，纳入了截至 2019 年 9 月 30 日发表的现有文献。
两名调查员使用 Cochrane 协作风险偏倚工具评估风险偏倚，并使用 GRADE（推荐评估、制定和评估分级）方法评估证据确定性。
使用除臭剂/止汗剂对放射性皮炎的发展没有影响。芦荟和鸸鹋油与标准护理等效或效果较差。口服姜黄素有轻微的有益作用。非甾体类局部干预措施对湿性脱皮的发展和瘙痒缓解有轻微的有益作用，同时导致 2 级放射性皮炎的风险略有增加。局部金盏花增加放射性皮炎的发病风险。局部类固醇和敷料均显示出减少放射性皮炎和湿性脱皮发展的益处，同时降低了患者报告的疼痛和瘙痒等症状的发生率。
对癌症患者放射性皮炎有效的症状管理策略包括局部非甾体类药物、局部类固醇和敷料。
