Institut de Chimie Moléculaire de l'Université de Bourgogne, ICMUB, UMR CNRS 6302, Université Bourgogne Franche-Comté, 9, Avenue Alain Savary, BP 47870, 21078 Dijon cedex, France.
Dalton Trans. 2020 Nov 10;49(43):15161-15170. doi: 10.1039/d0dt02511a.
The quantification of specific gases among thousands of VOCs (Volatile Organic Compounds) present in the human breath at the ppm/ppb level can be used to evidence the presence of diseases in the human body. The detection of these biomarkers in human exhaled breath through a noninvasive approach is an important field of research that is still attracting significant attention to this day. A portable device working at room temperature and usable directly on exhaled breath samples is still a challenge requiring a sensing material with high performances. The rich composition of the human breath implies that the sensing material must be highly selective and sensitive (ppm/ppb) in high relative humidity (RH) conditions and preferably at room temperature. The present work intends to provide a review on recent works in this application field through the use of porous materials and discuss the importance of Metal Organic Frameworks (MOFs) for such application. MOFs are highly porous crystalline materials often used for gas detection and capture, thus raising questions about their potential for detection in exhaled breath.
在人体呼吸中存在的数千种挥发性有机化合物（VOCs）中，对特定气体进行定量分析，可以证明人体存在疾病。通过非侵入性方法从人体呼出的气体中检测到这些生物标志物，是一个仍在吸引人们关注的重要研究领域。一种在室温下工作且可直接用于呼气样本的便携式设备仍然是一个挑战，需要具有高性能的传感材料。人体呼吸的丰富成分意味着，传感材料必须在高相对湿度（RH）条件下具有高度选择性和敏感性（ppm/ppb），并且最好在室温下工作。本工作旨在通过使用多孔材料，对该应用领域的最新研究工作进行综述，并讨论金属有机骨架（MOFs）在这种应用中的重要性。MOFs 是高度多孔的结晶材料，通常用于气体检测和捕获，因此引发了关于它们在呼气中检测潜力的问题。
