Department of Ophthalmology, Ocular Oncology Service, Ankara, Turkey.
Department of Pathology, Hacettepe University School of Medicine, Ankara, Turkey.
Ocul Immunol Inflamm. 2021 Apr 3;29(3):496-499. doi: 10.1080/09273948.2020.1815798. Epub 2020 Oct 16.
Our purpose is to report a patient with primary unilateral ciliary body marginal zone lymphoma who initially presented with hemorrhagic hypopyon.
Retrospective review of the clinical, imaging, and immunohistopathological features of the case was performed.
A 59-year-old man was referred with right anterior uveitis of unknown etiology which was unresponsive to systemic treatment. Slit-lamp biomicroscopy showed normotensive hemorrhagic hypopyon in that eye. Anterior segment ultrasound biomicroscopy revealed an iridociliary mass lesion. Because an anterior chamber paracentesis was noncontributory, a diagnostic cyclectomy was performed. Histopathological evaluation showed that the neoplastic cells were positive for CD20, lambda light chain, and BCL 2. BCL 6, CD10, CD5, SOX11, kappa, and Cyclin D1 stains were negative. The final diagnosis was extranodal marginal zone lymphoma of the ciliary body.
Although rare, ciliary lymphoma may be a cause of intractable anterior uveitis. Repeat biopsies could be carried out when there is a high level of clinical suspicion.
我们报告一例原发性单侧睫状体边缘区淋巴瘤患者，其最初表现为血性前房积血。
对该病例的临床、影像学和免疫组织病理学特征进行回顾性分析。
一名 59 岁男性因右眼不明原因的前葡萄膜炎就诊，全身治疗无效。裂隙灯生物显微镜检查显示该眼眼压正常的血性前房积血。眼前段超声生物显微镜显示虹膜睫状体肿块病变。由于前房穿刺术无明显作用，因此进行了诊断性睫状体切除术。组织病理学评估显示，肿瘤细胞 CD20、lambda 轻链和 BCL2 阳性，BCL6、CD10、CD5、SOX11、kappa 和 Cyclin D1 染色阴性。最终诊断为睫状体外边缘区淋巴瘤。
尽管罕见，但睫状体淋巴瘤可能是难治性前葡萄膜炎的原因。如果临床高度怀疑，可进行重复活检。
