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疫苗为何以及如何发挥作用。

Why and How Vaccines Work.

机构信息

Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA; Department of Molecular Cellular and Developmental Biology, Yale University, New Haven, CT 06510, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06520, USA; Department of Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Institute for Global Health, Yale University, New Haven, CT 06520, USA.

出版信息

Cell. 2020 Oct 15;183(2):290-295. doi: 10.1016/j.cell.2020.09.040.

DOI:10.1016/j.cell.2020.09.040
PMID:33064982
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7560117/
Abstract

Vaccines save millions of lives from infectious diseases caused by viruses and bacteria. As the world awaits safe and effective COVID-19 vaccines, we celebrate the progresses made and highlight challenges ahead in vaccines and the science behind them.

摘要

疫苗可预防病毒和细菌引起的传染病，拯救数百万人的生命。在全世界期待安全有效的 COVID-19 疫苗之际，我们庆祝所取得的进展，并强调疫苗及其背后科学所面临的挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2daa/7560117/898272f8b88f/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2daa/7560117/331316c1e223/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2daa/7560117/898272f8b88f/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2daa/7560117/331316c1e223/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2daa/7560117/898272f8b88f/gr2_lrg.jpg

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[1]
Why and How Vaccines Work.

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[2]
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[3]
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[4]
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引用本文的文献

[1]
Harnessing the Loop: The Perspective of Circular RNA in Modern Therapeutics.

Vaccines (Basel). 2025-7-31

[2]
Development of COVID-19 Vaccine Candidates Using Attenuated Recombinant Vesicular Stomatitis Virus Vectors with M Protein Mutations.

Viruses. 2025-7-30

[3]
Mapping the research landscape of immune response in human brucellosis: a bibliometric analysis.

Front Microbiol. 2025-7-29

[4]
Novel adjuvant delivery system constructed by alum-emulsion hybrid nanoparticles with TLR9 agonists boosts vaccine immunity.

J Nanobiotechnology. 2025-7-1

[5]
Next-Generation Vaccine Platforms: Integrating Synthetic Biology, Nanotechnology, and Systems Immunology for Improved Immunogenicity.

Vaccines (Basel). 2025-5-30

[6]
Current progress and challenges in the design and development of a successful COVID-19 vaccine.

Fundam Res. 2021-3

[7]
Immunotherapeutic Approach for Improving the Efficacy of a Novel Subunit Vaccine Against SARS-CoV-2 by Cytotoxic T-Lymphocytes (CTL) Epitopes.

Scientifica (Cairo). 2025-5-26

[8]
The recent advances in vaccine adjuvants.

Front Immunol. 2025-5-13

[9]
Nanotechnology-based strategies for vaccine development: accelerating innovation and delivery.

Biomater Transl. 2025-3-25

[10]
Toll-like receptor response to Zika virus infection: progress toward infection control.

Npj Viruses. 2025-3-13

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