Department of Agricultural Sciences, University of Naples Federico II, Portici 80055, Italy; Task Force on Microbiome Studies, University of Naples Federico II, Naples 80100, Italy.
Department of Agricultural Sciences, University of Naples Federico II, Portici 80055, Italy; Task Force on Microbiome Studies, University of Naples Federico II, Naples 80100, Italy.
Curr Biol. 2020 Dec 21;30(24):4932-4943.e4. doi: 10.1016/j.cub.2020.09.063. Epub 2020 Oct 15.
Faecalibacterium is prevalent in the human gut and a promising microbe for the development of next-generation probiotics (NGPs) or biotherapeutics. Analyzing reference Faecalibacterium genomes and almost 3,000 Faecalibacterium-like metagenome-assembled genomes (MAGs) reconstructed from 7,907 human and 203 non-human primate gut metagenomes, we identified the presence of 22 different Faecalibacterium-like species-level genome bins (SGBs), some further divided in different strains according to the subject geographical origin. Twelve SGBs are globally spread in the human gut and show different genomic potential in the utilization of complex polysaccharides, suggesting that higher SGB diversity may be related with increased utilization of plant-based foods. Moreover, up to 11 different species may co-occur in the same subject, with lower diversity in Western populations, as well as intestinal inflammatory states and obesity. The newly explored Faecalibacterium diversity will be able to support the choice of strains suitable as NGPs, guided by the consideration of the differences existing in their functional potential.
粪杆菌普遍存在于人类肠道中，是开发下一代益生菌（NGP）或生物治疗药物的有前途的微生物。分析参考粪杆菌基因组和近 3000 个来自 7907 个人类和 203 个非人类灵长类动物肠道宏基因组组装的粪杆菌样宏基因组组装基因组（MAG），我们确定了 22 种不同的粪杆菌样种水平基因组分箱（SGB）的存在，根据主体的地理来源，有些进一步分为不同的菌株。12 个 SGB 在全球范围内广泛存在于人类肠道中，在利用复杂多糖方面表现出不同的基因组潜力，这表明更高的 SGB 多样性可能与增加对植物性食物的利用有关。此外，多达 11 种不同的物种可能在同一主体中共存，西方人群的多样性较低，以及肠道炎症状态和肥胖。新探索的粪杆菌多样性将能够支持选择适合作为 NGP 的菌株，这是基于对其功能潜力存在差异的考虑。
