Center for Science and Engineering Living Systems (CSELS), Washington University, St. Louis, MO 63130, USA; Center for Engineering Mechanobiology, Washington University, St. Louis, MO 63130, USA; Department of Biology, Duke University, Durham, NC 27708, USA.
Center for Science and Engineering Living Systems (CSELS), Washington University, St. Louis, MO 63130, USA; Center for Engineering Mechanobiology, Washington University, St. Louis, MO 63130, USA; Department of Biology, Duke University, Durham, NC 27708, USA.
Mol Cell. 2020 Oct 15;80(2):181-182. doi: 10.1016/j.molcel.2020.09.026.
Some prion-like domains and low-complexity regions provide the multivalency required to facilitate protein phase separation to regulate protein function. Jung et al. (2020) demonstrate how natural selection of the ELF3 prion-like domain gives rise to an intuitive biological switch that directly responds to temperature.
一些类朊病毒结构域和低复杂度区域提供了促进蛋白质相分离以调节蛋白质功能所需的多价性。Jung 等人。（2020 年）展示了自然选择如何产生 ELF3 类朊病毒结构域，从而产生直接响应温度的直观生物开关。
