Fauser A A, Howson-Jan K, Kanz L, Löhr G W
Onkologie. 1987 Jun;10(3):144-52. doi: 10.1159/000216394.
Effective hematopoiesis is a multistep phenomenon. It consists in the presence of pluripotent hematopoietic stem cells (HSC), their proliferation and self-maintenance, their differentiation into various committed lineages of specific progenitors, their orderly maturation into functional cells that are released into the circulation in an orderly fashion in response to the body's demand. Increasing numbers of hematopoietic factors are being purified to homogeneity and/or cloned. The availability of sufficient quantities of these regulators promises a new area for research into the physiology and pathophysiology of the hematopoietic system. The purpose of this overview is to consider some newly-developed concepts in the field of hematopoiesis, with regard to regulatory control mechanisms and cellular interactions.
有效的造血是一个多步骤的过程。它包括多能造血干细胞（HSC）的存在、其增殖和自我维持、分化为各种特定祖细胞的定向谱系、有序成熟为功能性细胞，并根据身体需求有序释放到循环系统中。越来越多的造血因子已被纯化至同质和/或克隆。这些调节因子的充足供应为造血系统的生理学和病理生理学研究开辟了一个新领域。本综述的目的是探讨造血领域中一些关于调节控制机制和细胞相互作用的新发展概念。
