Hays K
Semin Oncol Nurs. 1990 Feb;6(1):3-8. doi: 10.1016/s0749-2081(05)80127-5.
The bone marrow is a richly innervated and highly vascularized tissue of the body responsible for hematopoiesis. The major functions include transporting oxygen, defense against foreign invasion, and hemostasis. An uncommitted pluripotent stem cell undergoes proliferation and differentiation in an orderly fashion, producing immature committed progenitors. The progenitors ultimately produce mature committed cells that are released into the circulating blood. Cell production is controlled by a variety of regulatory mechanisms, including growth factors. The availability of recombinant growth factors has stimulated clinical trials of these factors in a wide variety of hematologic diseases.
骨髓是人体中神经丰富且血管高度密集的组织，负责造血。其主要功能包括运输氧气、抵御外来入侵和止血。未定向的多能干细胞以有序方式进行增殖和分化，产生未成熟的定向祖细胞。这些祖细胞最终产生成熟的定向细胞并释放到循环血液中。细胞生成受多种调节机制控制，包括生长因子。重组生长因子的可得性推动了这些因子在多种血液疾病中的临床试验。
