Nissen C
Onkologie. 1987 Jun;10(3):153-6. doi: 10.1159/000216395.
Human serum contains stimulators of hemopoietic precursor cells. Isolation of "factors" from serum is technically more difficult than from supernatants due to interactions of "factors" with the high molecular weight serum proteins. On the other hand, serum factors are naturally occurring activities which are likely to play a role in regulation of hemopoiesis. Two hemopoietic stimulators which differ from the known colony stimulating factor have been found in human serum. One of them is an indirect "releaser" activity, which induces the release of granulocyte colony stimulating factor (G-CSF) from normal peripheral blood lymphocytes. In patients whose cells release abnormally low amounts of G-CSA, this serum activity is elevated, indicating a feedback mechanism between "releaser" activity and the actual release. G-CSA itself does not circulate in serum. Thus, we assume that releaser activity has a local effect in the bone marrow on the release of G-CSF. These observations suggest that hemopoiesis is regulated by multi-step hormonal mechanisms, in analogy to other known hormone systems.
人血清中含有造血前体细胞的刺激因子。由于“因子”与高分子量血清蛋白相互作用，从血清中分离“因子”在技术上比从上清液中分离更困难。另一方面，血清因子是天然存在的活性物质，可能在造血调节中发挥作用。在人血清中发现了两种不同于已知集落刺激因子的造血刺激因子。其中一种是间接“释放因子”活性，它能诱导正常外周血淋巴细胞释放粒细胞集落刺激因子（G-CSF）。在细胞释放G-CSA异常低的患者中，这种血清活性升高，表明“释放因子”活性与实际释放之间存在反馈机制。G-CSA本身并不在血清中循环。因此，我们认为释放因子活性在骨髓中对G-CSF的释放具有局部作用。这些观察结果表明，造血是由多步骤激素机制调节的，这与其他已知的激素系统类似。
