Department of Histology and Embryology, Akdeniz University School of Medicine, Antalya, Turkey.
Reproduction. 2020 Nov;160(5):R79-R94. doi: 10.1530/REP-20-0298.
The circadian system regulates the daily temporal organization in behavior and physiology, including neuroendocrine rhythms and reproduction. Modern life, however, increasingly impacts this complex biological system. Due to limitations of working with human subjects exposed to shift work schedules, most chronoregulation research has used rodent models. Recent publications in these model systems have emphasized the negative effects of circadian rhythm disruption on both female and male reproductive systems and fertility. Additionally, there is growing concern about the long-term effects of circadian rhythm disruptions during pregnancy on human offspring and their descendants as circadian regulation during pregnancy can also alter epigenetic programing in offspring. However, to truly know if such concerns apply to humans will require retrospective and prospective human studies. Therefore, this review will highlight the latest available evidence regarding potential effects of chronodisruption on both female and male reproductive systems. Additionally, it presents a comprehensive summary of transgenerational and epigenetic effects on adult offspring that result from maternal chronodisruption.
昼夜节律系统调节行为和生理的日常时间组织，包括神经内分泌节律和生殖。然而，现代生活日益影响这一复杂的生物系统。由于受到轮班工作时间表下的人类受试者的限制，大多数时间调节研究都使用了啮齿动物模型。这些模型系统中的最新出版物强调了昼夜节律破坏对女性和男性生殖系统和生育能力的负面影响。此外，人们越来越关注怀孕期间昼夜节律破坏对人类后代及其后代的长期影响，因为怀孕期间的昼夜节律调节也会改变后代的表观遗传编程。然而，要真正了解这些担忧是否适用于人类，将需要回顾性和前瞻性的人类研究。因此，本综述将重点介绍关于chronodisruption 对女性和男性生殖系统的潜在影响的最新可用证据。此外，它还全面总结了由于母体 chronodisruption 而导致成年后代的跨代和表观遗传效应。
