Danish Dementia Research Centre, Section 8007, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark.
Eur J Neurol. 2021 Feb;28(2):411-420. doi: 10.1111/ene.14595. Epub 2020 Nov 9.
Mortality following infections in dementia has not yet been comprehensively explored. The aim of this cohort study was to investigate the short- and long-term mortality following infections in dementia.
Follow-up was from 1 January 2000 or the 65-year birthday until death, immigration, or 31 December 2015. Exposure was incident dementia and a first infection. The outcome was all-cause mortality. Mortality rate ratios (MRRs) were calculated using Poisson regression in 4 exposure groups (dementia yes/no, infection yes/no) by sex, infection site, and time since infection.
1,496,436 people were followed with 12,739,135 person-years. MRR in dementia/infection was 6.52 (95% confidence interval: 6.43-6.60) and was increased for infections of all sites. Increased mortality was short term (30 days) and long term (10 years).
Increased mortality in people with dementia identifies them as a particularly vulnerable group that needs clinical attention.
痴呆患者感染后的死亡率尚未得到全面探讨。本队列研究旨在调查痴呆患者感染后的短期和长期死亡率。
随访时间为 2000 年 1 月 1 日或 65 岁生日，直至死亡、移民或 2015 年 12 月 31 日。暴露因素为新发痴呆和首次感染。结局为全因死亡率。采用泊松回归，根据性别、感染部位和感染后时间，在 4 个暴露组（痴呆有/无、感染有/无）中计算死亡率比（MRR）。
共随访 1,496,436 人，随访时间为 12,739,135 人年。痴呆/感染患者的 MRR 为 6.52（95%置信区间：6.43-6.60），所有部位感染的死亡率均增加。死亡率增加是短期的（30 天）和长期的（10 年）。
痴呆患者的死亡率增加表明他们是一个特别脆弱的群体，需要临床关注。
