Tsuboi Mayo, Niikura Ryota, Hayakawa Yoku, Hirata Yoshihiro, Ushiku Tetsuo, Koike Kazuhiko
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan.
Division of Advanced Genome Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo 108-863, Japan.
Biomedicines. 2020 Oct 14;8(10):419. doi: 10.3390/biomedicines8100419.
In Asia, the incidences of infection and gastric cancer are high, but their association with autoimmune gastritis (AIG) is unclear. This was a retrospective cohort study of patients endoscopically diagnosed with chronic gastritis between 2005 and 2017. AIG was diagnosed according to anti-parietal cell antibody positivity. Laboratory, histological findings, and gastric cancer incidence were compared between AIG and non-AIG patients. The AIG group had more females and a higher rate of thyroid disease. Serum levels of gastrin were significantly higher in AIG patients (mean 1412 and 353 pg/mL, < 0.001). The endoscopic findings included a significantly higher percentage of corpus-dominant atrophy in AIG (31.67%) than in non-AIG (7.04%) patients ( < 0.001). Clusters of ECL cells were observed in 28% of AIG patients and 7% of non-AIG patients ( = 0.032). The cumulative incidence of gastric cancer at 5 and 10 years was 0% and 0.03% in the AIG group and 0.03% and 0.05% in the non-AIG group, and no significant difference in gastric cancer incidence was observed. Despite significant differences in gastrin levels between AIG and non-AIG patients, there was no evidence of an impact of AIG on the incidence of gastric cancer.
在亚洲，感染和胃癌的发病率很高，但它们与自身免疫性胃炎（AIG）之间的关联尚不清楚。这是一项对2005年至2017年间经内镜诊断为慢性胃炎患者的回顾性队列研究。根据抗壁细胞抗体阳性诊断AIG。比较了AIG患者和非AIG患者的实验室检查、组织学结果及胃癌发病率。AIG组女性更多，甲状腺疾病发生率更高。AIG患者的血清胃泌素水平显著更高（平均分别为1412和353 pg/mL，<0.001）。内镜检查结果显示，AIG患者胃体为主型萎缩的比例（31.67%）显著高于非AIG患者（7.04%）（<0.001）。28%的AIG患者和7%的非AIG患者观察到肠嗜铬样细胞簇（P=0.032）。AIG组5年和10年胃癌的累积发病率分别为0%和0.03%，非AIG组分别为0.03%和0.05%，未观察到胃癌发病率有显著差异。尽管AIG患者和非AIG患者的胃泌素水平存在显著差异，但没有证据表明AIG对胃癌发病率有影响。
