Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada.
Int J Mol Sci. 2020 Oct 14;21(20):7595. doi: 10.3390/ijms21207595.
Mechanotransduction is the process in which cells can convert extracellular mechanical stimuli into biochemical changes within a cell. While this a normal process for physiological development and function in many organ systems, tumour cells can exploit this process to promote tumour progression. Here we summarise the current state of knowledge of mechanotransduction in osteosarcoma (OSA), the most common primary bone tumour, referencing both human and canine models and other similar mesenchymal malignancies (e.g., Ewing sarcoma). Specifically, we discuss the mechanical properties of OSA cells, the pathways that these cells utilise to respond to external mechanical cues, and mechanotransduction-targeting strategies tested in OSA so far. We point out gaps in the literature and propose avenues to address them. Understanding how the physical microenvironment influences cell signalling and behaviour will lead to the improved design of strategies to target the mechanical vulnerabilities of OSA cells.
机械转导是细胞将细胞外机械刺激转化为细胞内生化变化的过程。虽然这是许多器官系统中生理发育和功能的正常过程，但肿瘤细胞可以利用这个过程来促进肿瘤的进展。在这里，我们总结了骨肉瘤（OSA）中机械转导的最新知识状态，OSA 是最常见的原发性骨肿瘤，参考了人类和犬类模型以及其他类似的间充质恶性肿瘤（例如尤文肉瘤）。具体来说，我们讨论了 OSA 细胞的机械特性、这些细胞用于响应外部机械线索的途径，以及迄今为止在 OSA 中测试的机械转导靶向策略。我们指出了文献中的差距，并提出了解决这些差距的途径。了解物理微环境如何影响细胞信号转导和行为将导致改进设计靶向 OSA 细胞机械脆弱性的策略。
