Hegsted D M, Nicolosi R J
Proc Natl Acad Sci U S A. 1987 Sep;84(17):6259-61. doi: 10.1073/pnas.84.17.6259.
The intraindividual variances in serum/plasma cholesterol levels from a variety of sources have been examined. It is apparent that these are very substantial with mean coefficients of variation usually between 5% and 10%, even when the diet is controlled in metabolic studies. Some subjects show extreme variability from one blood sample to the next. Thus, it is very difficult to assess the degree of risk of individuals according to the guidelines provided by the Consensus Conference on lowering blood cholesterol levels to prevent heart disease, and many individuals will be misclassified unless particular attention is paid to this problem.
已对来自各种来源的血清/血浆胆固醇水平的个体内差异进行了研究。很明显，这些差异非常大，即使在代谢研究中控制饮食时，平均变异系数通常也在5%至10%之间。一些受试者的血液样本之间显示出极大的变异性。因此，根据降低血液胆固醇水平以预防心脏病的共识会议提供的指南来评估个体的风险程度非常困难，除非特别关注这个问题，否则许多个体将会被错误分类。
