Wolf R N, Grundy S M
Arteriosclerosis. 1983 Mar-Apr;3(2):160-9. doi: 10.1161/01.atv.3.2.160.
To determine the influence of weight reduction on plasma lipoproteins, studies were carried out in 15 nondiabetic patients of varying degrees of obesity and four obese insulin-dependent diabetics. All studies were carried out on a metabolic ward and patients underwent three dietary periods: Period I, 4 to 5 weeks of weight maintenance in the obese state; Period II, caloric restriction to 1000 kcal/day to a weight loss of within 10% of ideal body weight; and Period III, again weight maintenance for 4 to 5 weeks near ideal body weight. Similar results were obtained for both nondiabetics and diabetics. Many patients had mildly elevated plasma triglycerides in Period I; they fell to the normal range in Period II and remained low in Period III. Total cholesterol levels decreased early in Period II, but levels began to rise near the end of caloric restriction, and in Period III, they were similar to Period I. Low density lipoprotein cholesterol levels followed a pattern similar to that of total cholesterol. High density lipoprotein cholesterol was relatively low in Period I (38 +/- 2 mg/dl +/- SEM); throughout weight loss, levels tended to rise, and in Period III, the average high density lipoprotein cholesterol was significantly higher (46 +/- 2 mg/dl).
为了确定体重减轻对血浆脂蛋白的影响，对15名不同程度肥胖的非糖尿病患者和4名肥胖的胰岛素依赖型糖尿病患者进行了研究。所有研究均在代谢病房进行，患者经历了三个饮食阶段：第一阶段，在肥胖状态下维持体重4至5周；第二阶段，将热量摄入限制在1000千卡/天，直至体重减轻至理想体重的10%以内；第三阶段，在接近理想体重的情况下再次维持体重4至5周。非糖尿病患者和糖尿病患者均获得了相似的结果。许多患者在第一阶段血浆甘油三酯轻度升高；在第二阶段降至正常范围，并在第三阶段保持较低水平。总胆固醇水平在第二阶段早期下降，但在热量限制接近尾声时开始上升，在第三阶段，其水平与第一阶段相似。低密度脂蛋白胆固醇水平的变化模式与总胆固醇相似。高密度脂蛋白胆固醇在第一阶段相对较低（38±2毫克/分升±标准误）；在整个体重减轻过程中，其水平趋于上升，在第三阶段，平均高密度脂蛋白胆固醇显著升高（46±2毫克/分升）。
