Blank D W, Hoeg J M, Kroll M H, Ruddel M E
JAMA. 1986 Nov 28;256(20):2867-70.
Based on the results of recent clinical trials, physicians have been encouraged to screen and treat patients for hypercholesterolemia. Since the data from the Lipid Research Clinics (LRC) have been used to define the patient population that should be treated, a comparison of LRC cholesterol results with those obtained with two commonly used clinical laboratory instruments was performed. Both the Technicon SMAC and the Du Pont aca had positive bias compared with the LRC method. Therefore, many patients with cholesterol concentrations greater than 265 mg/dL (6.85 mmol/L) as determined by these routinely used methods have markedly lower levels determined by LRC methods. These findings not only indicate that rigorous interlaboratory standardization is required to conform to LRC reference values, but they also suggest that the clinician should be aware of these methodological considerations when the decision to treat hypercholesterolemia is made.
基于近期临床试验的结果，医生们受到鼓励对高胆固醇血症患者进行筛查和治疗。由于脂质研究诊所（LRC）的数据已被用于界定应接受治疗的患者群体，因此对LRC胆固醇检测结果与两种常用临床实验室仪器所获结果进行了比较。与LRC方法相比，Technicon SMAC和杜邦aca都存在正偏差。因此，许多通过这些常规使用方法测定胆固醇浓度大于265mg/dL（6.85mmol/L）的患者，其LRC方法测定的水平明显更低。这些发现不仅表明需要进行严格的实验室间标准化以符合LRC参考值，还提示临床医生在做出治疗高胆固醇血症的决定时应知晓这些方法学考量因素。
