The Pediatric Research in Emergency Therapeutics Program, Division of Emergency Medicine, Department of Pediatrics, University of British Columbia, British Columbia Children's Hospital Research Institute, Vancouver, British Columbia, Canada.
Department of Pediatric Emergency Medicine, Children's Medical Center of Dallas, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Clin Ther. 2020 Nov;42(11):2124-2133. doi: 10.1016/j.clinthera.2020.09.012. Epub 2020 Oct 3.
This study determined the predictors of caregivers' willingness to accept an accelerated regulatory process for the development of vaccines against coronavirus disease 2019 (COVID-19).
An international cross-sectional survey was administered to 2557 caregivers of children in 17 pediatric emergency departments (EDs) across 6 countries from March 26, 2020, to June 30, 2020. Caregivers were asked to select 1 of 4 choices with which they most agreed regarding a proposed COVID-19 vaccine-approval process, in addition to questions regarding demographic characteristics, the ED visit, and attitudes about COVID-19. Univariate analyses were conducted using the Mann-Whitney U test for comparing non-normally distributed continuous variables, an independent t test for comparing normally distributed continuous variables, and a χ or Fisher exact test for categorical variables. Multivariate logistic regression analysis was used for determining independent factors associated with caregivers' willingness to accept abridged development of a COVID-19 vaccine. A P value of <0.05 was considered significant.
Almost half (1101/2557; 43%) of caregivers reported that they were willing to accept less rigorous testing and postresearch approval of a new COVID-19 vaccine. Independent factors associated with caregivers' willingness to accept expedited COVID-19 vaccine research included having children who were up to date on the vaccination schedule (odds ratio [OR] = 1.72; 95% CI, 1.29-2.31), caregivers' concern about having had COVID-19 themselves at the time of survey completion in the ED (OR = 1.1; 95% CI, 1.05-1.16), and caregivers' intent to have their children vaccinated against COVID-19 if a vaccine were to become available (OR = 1.84; 95% CI, 1.54-2.21). Compared with fathers, mothers completing the survey were less likely to approve of changes in the vaccine-development process (OR = 0.641; 95% CI, 0.529-0.775).
Less than half of caregivers in this worldwide sample were willing to accept abbreviated COVID-19 vaccine testing. As a part of an effort to increase acceptance and uptake of a new vaccine, especially in order to protect children, public health strategies and individual providers should understand caregivers' attitudes toward the approval of a vaccine and consult them appropriately.
本研究旨在确定看护人愿意接受针对 2019 年冠状病毒病（COVID-19）疫苗的加速监管程序的预测因素。
2020 年 3 月 26 日至 6 月 30 日，在 6 个国家的 17 个儿科急诊部（ED）对 2557 名儿童的看护人进行了一项国际横断面调查。除了关于人口统计学特征、ED 就诊和对 COVID-19 的态度的问题外，看护人还被要求在拟议的 COVID-19 疫苗批准过程中选择 4 个选项之一，以表达他们最认同的选项。对于非正态分布的连续变量，使用 Mann-Whitney U 检验进行单变量分析，对于正态分布的连续变量，使用独立 t 检验进行比较，对于分类变量，使用 χ 或 Fisher 确切检验进行比较。使用多变量逻辑回归分析确定与看护人接受 COVID-19 疫苗简化开发意愿相关的独立因素。P 值<0.05 被认为具有统计学意义。
几乎一半（1101/2557；43%）的看护人表示，他们愿意接受对新的 COVID-19 疫苗进行更少的严格测试和研究后批准。与看护人愿意接受 COVID-19 疫苗研究加速相关的独立因素包括其子女已按计划接种疫苗（比值比[OR]，1.72；95%CI，1.29-2.31）、看护人在 ED 完成调查时对自己曾感染 COVID-19 的担忧（OR，1.1；95%CI，1.05-1.16）以及如果有疫苗，看护人打算让其子女接种 COVID-19 疫苗（OR，1.84；95%CI，1.54-2.21）。与父亲相比，完成调查的母亲不太可能赞成疫苗开发过程的改变（OR，0.641；95%CI，0.529-0.775）。
在这个全球样本中，不到一半的看护人愿意接受 COVID-19 疫苗测试的简化。作为增加对新疫苗的接受度和使用率的努力的一部分，特别是为了保护儿童，公共卫生策略和个别提供者应该了解看护人对疫苗批准的态度，并进行适当的咨询。
