Faculty of Medicine, Health and Human Sciences, Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, 2109, Australia.
Faculty of Medicine, Nursing and Health Sciences, Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, 3800, Australia.
Nat Commun. 2020 Oct 16;11(1):5301. doi: 10.1038/s41467-020-19045-9.
The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP's tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.
人类蛋白质组组织（HUPO）于 2010 年启动了人类蛋白质组计划（HPP），为全球合作、数据共享、质量保证以及增强对基因组编码蛋白质组的准确注释创建了一个国际框架。在随后的十年中，HPP 建立了合作关系，制定了指导方针和指标，并对先前存储的社区数据进行了重新分析，不断提高人类蛋白质组的覆盖率。在 HPP 成立十周年之际，我们在此报告了一个 90.4%完整的高强度人类蛋白质组蓝图。正如我们通过强调人类蛋白质组在我们对癌症、心血管和传染病的理解、诊断和治疗中的潜在作用所展示的那样，这一知识对于识别健康和疾病中的分子过程至关重要。
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