Department of Medicine Division of Endocrinology, Albert Einstein College of Medicine, Bronx, NY, USA.
Department of Respiratory and Critical Care Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.
Mol Psychiatry. 2021 Jul;26(7):2805-2819. doi: 10.1038/s41380-020-00908-y. Epub 2020 Oct 16.
It is essential to elucidate brain-adipocyte interactions in order to tackle obesity and its comorbidities, as the precise control of brain-adipose tissue cross-talk is crucial for energy and glucose homeostasis. Recent studies show that in the peripheral adipose tissue, adenosine induces adipogenesis through peripheral adenosine A receptor (pADORA) signaling; however, it remains unclear whether systemic and adipose tissue metabolism would also be under the control of central (c) ADORA signaling. Here, we use tissue-specific pharmacology and metabolic tools to clarify the roles of cADORA signaling in energy and adipocyte physiology. We found that cADORA signaling reduces body weight while also inducing adipose tissue lipolysis. cADORA signaling also increases adipose tissue sympathetic norepinephrine content. In contrast, pADORA signaling facilitates a high-fat diet-induced obesity (DIO). We propose here a novel mechanism in which cADORA and pADORA signaling hinder and aggravate DIO, respectively.
为了解决肥胖及其合并症的问题，阐明脑-脂肪细胞的相互作用至关重要，因为精确控制脑-脂肪组织的串扰对于能量和葡萄糖稳态至关重要。最近的研究表明，在外周脂肪组织中，腺苷通过外周腺苷 A 受体（pADORA）信号诱导脂肪生成；然而，目前尚不清楚全身和脂肪组织代谢是否也受到中枢（c）ADORA 信号的控制。在这里，我们使用组织特异性药理学和代谢工具来阐明 cADORA 信号在能量和脂肪细胞生理学中的作用。我们发现，cADORA 信号会降低体重，同时也会诱导脂肪组织脂肪分解。cADORA 信号还会增加脂肪组织交感神经去甲肾上腺素含量。相比之下，pADORA 信号促进高脂肪饮食诱导的肥胖（DIO）。我们在这里提出了一个新的机制，其中 cADORA 和 pADORA 信号分别阻碍和加重 DIO。
