Recent advances in biocatalytic derivatization of L-tyrosine.

L-Tyrosine is an aromatic, polar, non-essential amino acid that contains a highly reactive α-amino, α-carboxyl, and phenolic hydroxyl group. Derivatization of these functional groups can produce chemicals, such as L-3,4-dihydroxyphenylalanine, tyramine, 4-hydroxyphenylpyruvic acid, and benzylisoquinoline alkaloids, which are widely employed in the pharmaceutical, food, and cosmetics industries. In this review, we summarize typical L-tyrosine derivatizations catalyzed by enzymatic biocatalysts, as well as the strategies and challenges associated with their production processes. Finally, we discuss future perspectives pertaining to the enzymatic production of L-tyrosine derivatives.Key points• Summary of recent advances in enzyme-catalyzed L-tyrosine derivatization.• Highlights of relevant strategies involved in L-tyrosine derivatives biosynthesis.• Future perspectives on industrial applications of L-tyrosine derivatization.