寨卡病毒的病毒蛋白及其在病毒-宿主相互作用中的作用。
ZIKV viral proteins and their roles in virus-host interactions.
机构信息
State Key Laboratory of Virology, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China.
Department of Biological Sciences, Xi'an Jiaotong-Liverpool University, Suzhou, 215123, China.
出版信息
Sci China Life Sci. 2021 May;64(5):709-719. doi: 10.1007/s11427-020-1818-4. Epub 2020 Oct 14.
Abstract
The re-emergence of Zika virus (ZIKV) and its associated neonatal microcephaly and Guillain-Barré syndrome have led the World Health Organization to declare a global health emergency. Until today, many related studies have successively reported the role of various viral proteins of ZIKV in the process of ZIKV infection and pathogenicity. These studies have provided significant insights for the treatment and prevention of ZIKV infection. Here we review the current research advances in the functional characterization of the interactions between each ZIKV viral protein and its host factors.
摘要
寨卡病毒（ZIKV）的再次出现及其相关的新生儿小头畸形和吉兰-巴雷综合征已导致世界卫生组织宣布全球卫生紧急状态。直到今天，许多相关研究相继报道了 ZIKV 的各种病毒蛋白在 ZIKV 感染和致病性过程中的作用。这些研究为 ZIKV 感染的治疗和预防提供了重要的见解。在这里，我们回顾了 ZIKV 病毒蛋白与其宿主因子之间相互作用的功能特征的最新研究进展。
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