Brandão Pedro Renato P, Munhoz Renato Puppi, Grippe Talyta Cortez, Cardoso Francisco Eduardo Costa, de Almeida E Castro Brenda Macedo, Titze-de-Almeida Ricardo, Tomaz Carlos, Tavares Maria Clotilde Henriques
Laboratory of Neuroscience and Behavior, Institute of Biological Sciences, Universidade de Brasília (UnB); Neurology Section, Medical Department, Chamber of Deputies of the Federal Republic of Brazil, Brasília, DF, Brazil.
Toronto Western Hospital, Movement Disorders Centre, Toronto Western Hospital - UHN, Division of Neurology, University of Toronto, Toronto, Canada.
J Neurol Sci. 2020 Dec 15;419:117177. doi: 10.1016/j.jns.2020.117177. Epub 2020 Oct 11.
Cognitive dysfunction in Parkinson's disease (PD) has received increasing attention, and, together with other non-motor symptoms, exert a significant functional impact in the daily lives of patients. This article aims to compile and briefly summarize selected published data about clinical features, cognitive evaluation, biomarkers, and pathophysiology of PD-related dementia (PDD). The literature search included articles indexed in the MEDLINE/PubMed database, published in English, over the last two decades. Despite significant progress on clinical criteria and cohort studies for PD-mild cognitive impairment (PD-MCI) and PDD, there are still knowledge gaps about its exact molecular and pathological basis. Here we overview the scientific literature on the role of functional circuits, neurotransmitter systems (monoaminergic and cholinergic), basal forebrain, and brainstem nuclei dysfunction in PD-MCI. Correlations between neuroimaging and cerebrospinal fluid (CSF) biomarkers, clinical outcomes, and pathological results are described to aid in uncovering the neurodegeneration pattern in PD-MCI and PDD.
帕金森病（PD）中的认知功能障碍已受到越来越多的关注，并且与其他非运动症状一起，对患者的日常生活产生重大功能影响。本文旨在汇编并简要总结有关帕金森病相关痴呆（PDD）的临床特征、认知评估、生物标志物和病理生理学的部分已发表数据。文献检索包括过去二十年中在MEDLINE/PubMed数据库中索引的、以英文发表的文章。尽管在PD-轻度认知障碍（PD-MCI）和PDD的临床标准和队列研究方面取得了重大进展，但关于其确切分子和病理基础仍存在知识空白。在此，我们概述了关于功能回路、神经递质系统（单胺能和胆碱能）、基底前脑和脑干核功能障碍在PD-MCI中的作用的科学文献。描述了神经影像学与脑脊液（CSF）生物标志物、临床结果和病理结果之间的相关性，以帮助揭示PD-MCI和PDD中的神经退行性变模式。
