Physical Therapy Department, Universidade Federal de Pernambuco, Recife, Brazil.
Physical Therapy Department, Universidade Federal do Rio Grande do Norte, Natal, Brazil.
Arch Gerontol Geriatr. 2021 Jan-Feb;92:104279. doi: 10.1016/j.archger.2020.104279. Epub 2020 Oct 9.
To investigate the association between frailty and a summary cardiovascular risk measure (Framingham Risk Score, FRS) in a sample of older adults from different epidemiologic contexts participating in the multicenter International Mobility in Aging Study (IMIAS).
This cross-sectional study used data from the IMIAS, which is composed of older adults from four different countries (Canada, Albania, Colombia and Brazil). A total of 1724 older adults aged 65-74 years were assessed. Frailty was defined as the presence of 3 or more of the following criteria: unintentional weight loss in the last year, exhaustion, muscle weakness, slowness in gait speed, and low levels of physical activity. The FRS was calculated to estimate the 10-year risk for cardiovascular disease (CVD), based on: sex, age, systolic blood pressure (SBP), and treatment for hypertension, total and high-density lipoprotein (HDL) cholesterol, diabetes mellitus status and smoking habits. Confounders included measures of childhood social and economic adversity, as well as mid-life and adult adversity.
After adjustment for adversities which occurred during in early, adult or current life, frail individuals presented higher FRS values (β = 3.81, 95 %CI: 0.97-6.65, p-value <0.001) when compared to robust participants. A statistically significant relationship was also observed in prefrail participants with FRS (β = 1.61, 95 % CI: 0.72-3.02, p-value <0.05).
Frailty and prefrailty were associated to FRS, independent of life course adversities. Screening cardiovascular risk factors should be a target, mainly in those who present frailty syndrome.
在参与多中心国际老龄化迁移研究（IMIAS）的不同流行病学背景的老年人群体中，研究衰弱与综合心血管风险评估指标（弗雷明汉风险评分，FRS）之间的关联。
这项横断面研究使用了来自 IMIAS 的数据，该研究由来自四个不同国家（加拿大、阿尔巴尼亚、哥伦比亚和巴西）的老年人组成。共有 1724 名 65-74 岁的老年人参与了评估。衰弱被定义为存在以下 3 种或更多情况：过去一年体重意外减轻、疲惫、肌肉无力、步态速度缓慢和体力活动水平低。FRS 是根据性别、年龄、收缩压（SBP）和高血压治疗情况、总胆固醇和高密度脂蛋白（HDL）胆固醇、糖尿病状态和吸烟习惯计算得出，用于估计 10 年内患心血管疾病（CVD）的风险。混杂因素包括童年社会和经济逆境以及中年和成年逆境的测量值。
在调整了早期、成年或当前生活中发生的逆境后，与健康的参与者相比，衰弱的个体的 FRS 值更高（β=3.81，95%CI：0.97-6.65，p<0.001）。在处于虚弱前期的参与者中，也观察到了与 FRS 有统计学意义的关系（β=1.61，95%CI：0.72-3.02，p<0.05）。
衰弱和虚弱前期与 FRS 相关，独立于生活轨迹中的逆境。筛查心血管危险因素应该是一个目标，特别是针对那些存在衰弱综合征的人。
