Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Queen's University, Victory 4, 76 Stuart St., Kingston, ON, K7L 2V7, Canada; Department of Public Health Sciences, Queen's University, Carruthers Hall 2nd Floor, 62 Fifth Field Company Lane, Kingston, ON, K7L 3N6, Canada.
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Queen's University, Victory 4, 76 Stuart St., Kingston, ON, K7L 2V7, Canada.
Maturitas. 2019 Apr;122:22-30. doi: 10.1016/j.maturitas.2018.12.015. Epub 2018 Dec 27.
Grip strength and gait speed are objective measures of physical function, which in turn is an indicator of biological aging. We evaluate the association between age at natural menopause (ANM) and physical functioning in a sample of postmenopausal women drawn from the International Mobility in Aging Study (IMIAS).
Retrospective cohort study of 775 women aged 65-74, from Albania, Brazil, Colombia and Canada, who had experienced natural menopause.
Gait speed and grip strength were obtained following standardized protocols. The association between self-reported ANM (<40, 40-44, 45-49, 50-54 and ≥55) and gait speed (m/s) and grip strength (kg) was assessed by linear regression analyses adjusting for several life-course economic and reproductive exposures, height, BMI and smoking.
Overall, women with ANM ≥ 55 had higher gait speed than those with ANM 50-54 (β = 0.05; 95%CI: 0.01, 0.10). Women with ANM < 40 had significantly lower grip strength compared with all other groups (β= -2.58; 95%CI: -4.43, -0.74). In region-specific analyses, ANM was associated with grip strength in Albania and Latin America and with gait speed in Albania only. No associations were observed in Canada.
ANM is associated with markers of physical functioning. Differences across study sites suggest that women in socially disadvantaged areas may reach menopause with different physiological reserves than those from more advantaged settings, leading to greater losses in muscle strength in postmenopausal years. More work comparing distinct populations is needed to better understand the underlying mechanisms.
握力和步速是身体功能的客观衡量标准，而身体功能又是生物衰老的一个指标。我们评估了自然绝经年龄（ANM）与来自国际老龄化迁移研究（IMIAS）的绝经后女性样本的身体功能之间的关联。
这是一项对来自阿尔巴尼亚、巴西、哥伦比亚和加拿大的 775 名年龄在 65-74 岁之间、经历过自然绝经的女性进行的回顾性队列研究。
采用标准化方案获取步速和握力。通过线性回归分析，调整了多项生命历程经济和生殖暴露、身高、BMI 和吸烟情况，评估了报告的 ANM（<40、40-44、45-49、50-54 和≥55）与步速（m/s）和握力（kg）之间的关联。
总体而言，ANM≥55 的女性步速高于 ANM 50-54 的女性（β=0.05；95%CI：0.01，0.10）。与其他所有组相比，ANM<40 的女性握力明显较低（β=-2.58；95%CI：-4.43，-0.74）。在特定区域分析中，ANM 与阿尔巴尼亚和拉丁美洲的握力相关，仅与阿尔巴尼亚的步速相关。在加拿大未观察到关联。
ANM 与身体功能的标志物相关。不同研究地点之间的差异表明，社会处境不利地区的女性在绝经时可能具有与处于更有利环境中的女性不同的生理储备，导致绝经后肌肉力量损失更大。需要更多比较不同人群的工作，以更好地理解潜在机制。
