Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Bone. 2022 May;158:115693. doi: 10.1016/j.bone.2020.115693. Epub 2020 Oct 15.
Metastasis is responsible for a large majority of death from malignant solid tumors. Bone is one of the most frequently affected organs in cancer metastasis, especially in breast and prostate cancer. Development of bone metastasis requires cancer cells to successfully complete a number of challenging steps, including local invasion and intravasation, survival in circulation, extravasation and initial seeding, and finally, formation of metastatic colonies after a period of dormancy or indolent growth. During this process, cancer cells often undergo a series of cellular and molecular changes to gain cellular plasticity that helps them adapt to various environments they encounter along the journey of metastasis. Understanding the mechanisms behind cellular plasticity and adaptation during the formation of bone metastasis is crucial for the development of novel therapies.
转移是导致恶性实体肿瘤患者死亡的主要原因。骨骼是癌症转移最常累及的器官之一，尤其是乳腺癌和前列腺癌。骨转移的发展需要癌细胞成功完成多个具有挑战性的步骤，包括局部侵袭和血管内渗、在循环中存活、血管外渗和初始定植，以及在休眠或惰性生长一段时间后最终形成转移性集落。在此过程中，癌细胞通常会经历一系列细胞和分子变化，从而获得细胞可塑性，帮助它们适应转移过程中遇到的各种环境。了解骨转移形成过程中细胞可塑性和适应性的机制对于开发新的治疗方法至关重要。
