Brams A, Buchet J P, Crutzen-Fayt M C, De Meester C, Lauwerys R, Léonard A
Toxicol Lett. 1987 Sep;38(1-2):123-33. doi: 10.1016/0378-4274(87)90120-2.
A comparison was made, for 40 compounds belonging to different chemical classes, of the mutagenicity as measured by the Salmonella assay and of the SOS-inducing potency as measured by the SOS chromotest kit procedure. It was found that most (78%) of the chemicals described as mutagens/carcinogens (14 compounds) were detected with a simplified Ames test procedure, using 3 strains (TA 97, TA 98, TA 100) and 3 concentrations of the tested material. The SOS chromotest, carried out following the recommendations of the commercially available kits, revealed that only 4 Ames test-positive compounds were mutagenic towards E. coli strain PQ 37.
对属于不同化学类别的40种化合物进行了比较，比较了用沙门氏菌试验测定的诱变性和用SOS显色试验试剂盒程序测定的SOS诱导能力。结果发现，使用3种菌株（TA 97、TA 98、TA 100）和3种受试物质浓度的简化艾姆斯试验程序，检测出了大多数（78%）被描述为诱变剂/致癌物的化学物质（14种化合物）。按照市售试剂盒的建议进行的SOS显色试验表明，只有4种艾姆斯试验阳性化合物对大肠杆菌菌株PQ 37具有诱变性。
