Emig M, Reinhardt A, Mersch-Sundermann V
Institut für Medizinische und Hygiene, Klinikum Mannheim, Germany.
Toxicol Lett. 1996 Jun;85(3):151-6. doi: 10.1016/0378-4274(96)03667-3.
Five nitro musk compounds widely used in cosmetics and detergents were examined for DNA-damaging and mutation-inducing properties. For this purpose two short-time assays were used, the SOS chromotest and the Salmonella/mammalian microsome test. Musk ambrette showed mutagenicity in Salmonella typhimurium TA 100 requiring metabolic activation by rat liver postmitochondrial supernatant (S9) but it lacked mutagenicity in the absence of S9 and genotoxicity in the SOS chromotest. Musk xylene, musk ketone, musk moskene and musk tibetene showed neither mutagenicity nor genotoxicity in the presence and absence of S9.
对广泛用于化妆品和洗涤剂中的五种硝基麝香化合物的DNA损伤和致突变特性进行了检测。为此，使用了两种短期检测方法，即SOS显色试验和沙门氏菌/哺乳动物微粒体试验。葵子麝香在鼠伤寒沙门氏菌TA 100中显示出致突变性，需要大鼠肝线粒体后上清液（S9）进行代谢激活，但在无S9时缺乏致突变性，且在SOS显色试验中无遗传毒性。二甲苯麝香、酮麝香、二甲苯麝香和西藏麝香在有或无S9的情况下均未显示出致突变性或遗传毒性。
