Sutton K C, Wolfson S K, Kuller L H
Stroke. 1987 Sep-Oct;18(5):817-22. doi: 10.1161/01.str.18.5.817.
The prevalence of carotid and lower extremity arterial disease was assessed in a healthy population of 56 elderly adults with isolated systolic hypertension. Duplex scans were performed to determine the extent of carotid disease, and postexercise ratios of ankle to arm systolic blood pressure were measured to assess lower extremity arterial disease. Internal carotid stenosis was found in 38% (21 of 56) of subjects and lower extremity arterial disease in 42% (23 of 55). The strongest predictor of internal carotid stenosis was lower extremity arterial disease. Independent risk factors for lower extremity arterial disease were smoking, internal carotid stenosis, and age. A measure of extent of carotid plaque was found to correlate with age, carotid stenosis, male sex, history of smoking, and total cholesterol. The high prevalence of peripheral vascular disease in this population may be related to their age and blood pressure. The high correlation between carotid stenosis and lower extremity arterial disease suggests that persons with peripheral vascular disease should be assessed and treated for atherosclerotic disease in general.
在56名患有单纯收缩期高血压的健康老年人群中评估了颈动脉和下肢动脉疾病的患病率。进行双功扫描以确定颈动脉疾病的程度，并测量运动后踝臂收缩压比值以评估下肢动脉疾病。在38%（56例中的21例）的受试者中发现颈内动脉狭窄，在42%（55例中的23例）的受试者中发现下肢动脉疾病。颈内动脉狭窄的最强预测因素是下肢动脉疾病。下肢动脉疾病的独立危险因素是吸烟、颈内动脉狭窄和年龄。发现颈动脉斑块程度的一项指标与年龄、颈动脉狭窄、男性、吸烟史和总胆固醇相关。该人群中周围血管疾病的高患病率可能与其年龄和血压有关。颈动脉狭窄与下肢动脉疾病之间的高度相关性表明，一般而言，患有周围血管疾病的人应接受动脉粥样硬化疾病的评估和治疗。
