Department of Neurosurgery, The First Affiliated Hospital of JiNan University, Guangzhou, Guangdong Province, 510632, P. R. China.
J Integr Neurosci. 2020 Sep 30;19(3):437-442. doi: 10.31083/j.jin.2020.03.25.
Brainstem hemorrhage is presumed to be invariably associated with a poor prognosis in people with spontaneous hypertensive cerebral hemorrhage. The optimal timing of tracheostomy placement in brainstem hemorrhage patients, who generally require endotracheal intubation for airway protection, remains uncertain. Our research aim was to analyze the impact of early tracheostomy versus late tracheostomy on brainstem hemorrhage patients related outcomes and prognostic factors at 30 days. We identified early tracheostomy and how it could benefit the patients with brainstem hemorrhage and ameliorate the predictors of functional recovery at 30 days. Data on 136 patients with brainstem hemorrhage and Glasgow Coma Scale score ≤ 8, were retrospectively collected from 2012 to 2019. Patients were divided into the early tracheostomy group and the late tracheostomy group. Patients in the early tracheostomy group had a significantly lower neurosurgical intensive care unit stay (both overall and survival) compared with the late tracheostomy group (15.6 days vs. 19.0 days, = 0.041, overall and 14.5 vs. 19.5 days, = 0.023, survival). Also, the good outcomes (modified Rankin Score ≤ 3) were higher in the early tracheostomy group ( = 0.036). Multivariate analysis demonstrated that less hemorrhagic volume, high Glasgow Coma Scale score on admission, young age, and early tracheostomy were significantly associated with a better 30-day functional outcome. In conclusion, an early tracheostomy in patients with brainstem hemorrhage can reduce neurosurgical intensive care unit stay, and in addition to improvements in prognosis at 30 days.
脑干出血被认为与自发性高血压性脑出血患者的预后不良有关。对于需要气管插管保护气道的脑干出血患者,气管切开术的最佳时机仍不确定。我们的研究目的是分析早期气管切开术与晚期气管切开术对脑干出血患者相关结局和 30 天预后因素的影响。我们确定了早期气管切开术及其如何使脑干出血患者受益,并改善 30 天的功能恢复预测因素。2012 年至 2019 年,我们回顾性地收集了 136 例脑干出血和格拉斯哥昏迷量表评分≤8 的患者的数据。患者分为早期气管切开组和晚期气管切开组。与晚期气管切开组相比,早期气管切开组患者神经外科重症监护病房住院时间(包括总住院时间和存活时间)明显缩短(15.6 天比 19.0 天, = 0.041,总住院时间和 14.5 天比 19.5 天, = 0.023,存活时间)。此外,早期气管切开组的良好结局(改良 Rankin 评分≤3)更高( = 0.036)。多变量分析表明,出血量较少、入院时格拉斯哥昏迷量表评分较高、年龄较小和早期气管切开术与 30 天功能预后较好显著相关。总之,脑干出血患者的早期气管切开术可以减少神经外科重症监护病房的住院时间,并改善 30 天的预后。